Fine Particle Air Pollution and Physiological Reactivity to Social Stress in Adolescence: The Moderating Role of Anxiety and Depression

Miller, Jonas G.; Gillette, Julia S.; Manczak, Erika M.; Kircanski, Katharina; Gotlib, Ian H.

doi:10.1097/psy.0000000000000714

Cited by 43 publications

(54 citation statements)

References 40 publications

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“…We used participant-reported addresses to estimate neighborhood quality via census tract information provided by CalEnviroScreen ( https://oehha.ca.gov/calenviroscreen ), an online tool created by the Office of Environmental Health Hazard Assessment on behalf of the California Environmental Protection Agency. Neighborhood disadvantage was computed using average percentile values of housing burden, unemployment, education, and poverty relative to other census tracts in California ( 69 ). If participants moved between T1 and the COVID-19 assessments, we used their updated addresses to estimate this information.…”

Section: Methodsmentioning

confidence: 99%

Higher Executive Control Network Coherence Buffers Against Puberty-Related Increases in Internalizing Symptoms During the COVID-19 Pandemic

Chahal

Kirshenbaum

Miller

et al. 2021

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background Early pubertal maturation has been posited to be a biopsychosocial risk factor for the onset of internalizing psychopathology in adolescence; further, early-maturing youth exhibit heightened reactivity to stressful events. School closures and enforced social distancing, as well as health and financial uncertainties, during the COVID-19 pandemic are expected to adversely affect mental health in youth, particularly adolescents who are already at risk for experiencing emotional difficulties. The executive control network (ECN) supports cognitive processes required to successfully navigate novel challenges and regulate emotions in stressful contexts. Methods : We examined whether functional coherence of the ECN, measured using resting-state fMRI five years before the pandemic (at T1), is a neurobiological marker of resilience to increases in the severity of internalizing symptoms during COVID-19 in adolescents who were in more advanced stages of puberty at T1 relative to their same-age peers (N=85; 49 F). Results On average, participants reported an increase in symptoms from the three months prior to pandemic to the two most recent weeks during the pandemic. We found that early-maturing youth exhibited greater increases in internalizing symptoms during the pandemic if their ECN coherence was low; in contrast, relative pubertal stage was not associated with changes in internalizing symptoms in adolescents with higher ECN coherence at T1. Conclusions These findings highlight the role of the functional architecture of the brain that supports executive functioning in protecting against risk factors that may exacerbate symptoms of internalizing psychopathology during periods of stress and uncertainty.

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Section: Methodsmentioning

confidence: 99%

Higher Executive Control Network Coherence Buffers Against Puberty-Related Increases in Internalizing Symptoms During the COVID-19 Pandemic

Chahal

Kirshenbaum

Miller

et al. 2021

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…SCL reactivity was calculated in the same manner. RSA and SCL recovery were calculated by averaging values across both recovery periods and subtracting the average of the story and math scores from these recovery scores (Miller, Gillette, Manczak, Kircanski, & Gotlib, 2019).…”

Section: Methodsmentioning

confidence: 99%

“…Autonomic regulation was operationalized by combining standardized RSA and SCL change values, thereby representing physiological shifts from sympathetic nervous system (SNS) activity to parasympathetic nervous system (PNS) activity (Miller et al, 2019). RSA and SCL change values were z-scored for standardization.…”

Section: Autonomic Regulation During Stressmentioning

confidence: 99%

Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents

Pham

Miller

et al. 2020

Dev Psychopathol

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Social anxiety disorder (SAD) is commonly diagnosed during adolescence and is associated with psychological stress reactivity and heightened physiological arousal. No study, however, has systematically examined which aspects of autonomic nervous system function mediate likely links between stress sensitivity and social anxiety symptoms in adolescents. Here, we assessed 163 adolescents (90 females; 12.29 ± 1.39 years) with respect to life stress and social anxiety symptoms, and measured respiratory sinus arrhythmia (RSA) and skin conductance levels (SCL) during a psychosocial stress paradigm. We operationalized stress sensitivity as the residual variance in subjective stress severity after accounting for objective severity and changes in autonomic regulation using standardized change scores in RSA and SCL. In females only, stress sensitivity and social anxiety symptoms were significantly correlated with each other (p < .001) and with autonomic regulation during both reactivity and recovery (all ps < 0.04). Further, sympathetic nervous system dominance during recovery specifically mediated associations between stress sensitivity and social anxiety symptoms (B = 1.06, 95% CI: 0.02–2.64). In contrast, in males, stress sensitivity, autonomic regulation during reactivity or recovery, and social anxiety symptoms were not significantly associated (all ps > 0.1). We interpret these results in the context of psychobiological models of SAD and discuss implications for interventions targeting autonomic processes.

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“…SCL reactivity was calculated in the same manner. RSA and SCL recovery were calculated by averaging values across both recovery periods and subtracting from the average of the story and math scores (Miller, Gillette, Manczak, Kircanski, & Gotlib, 2019).…”

Section: Autonomic Regulation During Stressmentioning

confidence: 99%

Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents

Ho¹,

Pham²,

Miller³

et al. 2020

Preprint

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Social anxiety disorder (SAD) is one of the most common anxiety disorders diagnosed during adolescence. SAD is associated with both psychological stress reactivity and heightened physiological arousal; however, no study has systematically examined which aspects of autonomic nervous system function mediate the likely links between stress sensitivity and symptoms of SAD in adolescents. In this study, we assessed 163 adolescents (90 females; 12.29±1.39 years) with respect to severity of life stress and social anxiety symptoms and measured respiratory sinus arrhythmia (RSA) and skin conductance levels (SCL) during a well-validated psychosocial stress paradigm composed of baseline, reactivity, and recovery periods. We operationalized stress sensitivity as the residual variance in subjective stress severity after accounting for objective stress severity and changes in autonomic regulation (relative to baseline) during reactivity and recovery using standardized change scores in RSA and SCL. We found that in females only, stress sensitivity and symptoms of SAD were significantly correlated with each other (p<0.001) and with autonomic regulation during both reactivity and recovery (all ps<0.04). Further, sympathetic nervous system dominance during recovery specifically mediated associations between stress sensitivity and symptoms of SAD (B=1.06, 95% CI: 0.02–2.64). In contrast, in males, stress sensitivity, autonomic regulation during reactivity or recovery, and symptoms of SAD were not significantly associated (all ps>0.1). We interpret these results in the context of psychobiological models of SAD and discuss implications for interventions targeting autonomic processes in this disorder.

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Fine Particle Air Pollution and Physiological Reactivity to Social Stress in Adolescence: The Moderating Role of Anxiety and Depression

Cited by 43 publications

References 40 publications

Higher Executive Control Network Coherence Buffers Against Puberty-Related Increases in Internalizing Symptoms During the COVID-19 Pandemic

Higher Executive Control Network Coherence Buffers Against Puberty-Related Increases in Internalizing Symptoms During the COVID-19 Pandemic

Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents

Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents

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