Fine particulate matter in acute exacerbation of COPD

Ni, Lei; Chuang, Chia‐Chen; Zuo, Li

doi:10.3389/fphys.2015.00294

Cited by 137 publications

(68 citation statements)

References 109 publications

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“…Particulate pollution is a serious environmental problem that is influencing air quality as well as regional and global climates, and epidemiological surveys show that air pollution may have negative effects on the human body, especially the respiratory system (Pope et al 2002; Balashazy et al 2003; Pope et al 2009; Shah et al 2013; Atkinson et al 2014; Beelen et al 2015). Additionally, numerous investigations on PM2.5 and human health were reported, mainly focusing on its cytotoxic effects (Laing et al 2010; Ma et al 2015; Deng et al 2014) and effect of reactive oxygen species (Ni et al 2015; Zuo et al 2012; Jiang et al 2014). The contributions of PM2.5, the main toxicological component of air pollution, to lung cancer are complex, and the specific mechanisms through which different genes regulate lung tumor growth and progression are not well defined.…”

Section: Discussionmentioning

confidence: 99%

The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferation

et al. 2016

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BackgroundIncreasing urbanization and associated air pollution, including elevated levels of particulate matter (PM), are strongly correlated with the development of various respiratory diseases. In particular, PM2.5 has been implicated in promoting lung cancer initiation, growth and progression. Cell migration and proliferation are crucial for the progression of cancer. However, the molecular signatures and biological networks representing the distinct and shared features of non-small cell lung cancer (NSCLC) after PM2.5 exposure are unknown.ResultsFunctional assays demonstrated higher proliferation, migration and invasion of cancer cells stimulated with PM2.5. To investigate the complicated mechanisms, we performed global transcriptome profiling of the A549 cell line. Particularly, transcriptome sequencing revealed invasive characteristics reminiscent of cancer cells. By comparing the transcriptomes, we identified distinct molecular signatures and cellular processes defining the invasive and proliferative properties of PM2.5-exposed cells, respectively. Interestingly, under the PM2.5-stimulated condition, the A549 and H1299 cells strengthened obviously properties in motility and proliferation. Based on the network model reconstructing the shared protein–protein interactions, we selected the two most up-regulated genes, interleukin-1β (IL1β) and matrix metalloprotease 1 (MMP1), as key regulators responsible for the effects of PM2.5 exposure. Notably, IL1β and MMP1 expression was elevated in independent assays, which was further enhanced by PM2.5.ConclusionTaken together, our systems approach to investigating PM2.5 exposure provides a basis to identify key regulators responsible for the pathological features of NSCLC.

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Section: Discussionmentioning

confidence: 99%

The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferation

et al. 2016

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“…Although the exact mechanisms remain unclear, airway inflammation is widely believed to play a critical role in the development of PM 2.5 -induced respiratory diseases (Falcon-Rodriguez et al, 2016;Harkema et al, 2009;Ni et al, 2015). Fractional exhaled nitric oxide (FeNO) is a well-established airway inflammatory biomarker employed in both clinical practice and epidemiological studies due to its high reproducible and noninvasive nature (Adamkiewicz et al, 2004;American Thoracic and European Respiratory, 2005;Dales et al, 2008;Dweik et al, 2011;Liu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Association between fine particulate matter chemical constituents and airway inflammation: A panel study among healthy adults in China

Shi

Chen

Yang

et al. 2016

Environmental Research

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“…Many epidemiological studies have provided evidence of association between the exposure to PM and asthma, bronchitis and chronic obstructive pulmonary disease, as well as cardiovascular diseases (van Berlo et al, 2012). Closeness to highly polluted locations, such as heavy traffic streets, reveals to be a risk factor for respiratory complications in vulnerable population, leading to reduction of pulmonary function (Peters et al, 1999;Fritz and Herbarth, 2001;Kim et al, 2004;Calderón-Garcidueñas et al, 2006;Ni et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Air Pollution alongside Bike-Paths in Bogotá-Colombia

Franco

Segura

Mura

2016

Front. Environ. Sci.

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The study we present in this paper aims at characterizing the range of fine particulate matter (PM 2.5 ) and black carbon (BC) concentrations to which bike-path users in Bogotá are exposed to. Using a bike equipped with a DustTrak and a micro-aethalometer we measured PM 2.5 and BC concentration levels along bike-paths corridors, during weekdays and weekends. Experiments were conducted in fours streets, representing four typical configurations of bike-paths in the city. Traffic data for workdays was also available from local mobility authority. Results indicate that bike-paths users in Bogotá are exposed to air pollution levels far exceeding the threshold values established as potentially dangerous for human health. Average concentrations for PM 2.5 ranged between 80 and 136 ug/m 3 in workdays and between 30 and 72 ug/m 3 in weekends. BC mean concentrations were between 16 and 38 µg/m 3 during workdays and in the range 10-32 µg/m 3 during weekends. A statistically significant difference exists in the levels of pollutants concentrations measured during workdays and weekends for all the considered bike paths. According to our results, both traffic volume and diffusions conditions, which are affected by many factors including street geometry, affect bike-path user's exposure levels. Taking into account the important role that bicycling is playing as an alternative transport mode in Latin American cities, we consider these results provide useful insights to increase the appreciation of the excessive bikers' exposure to air pollution in Bogotá. Moreover, these findings contribute with technical elements that should lead to the inclusion of air quality variable when designing and planning sustainable urban mobility infrastructures.

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Fine particulate matter in acute exacerbation of COPD

Cited by 137 publications

References 109 publications

The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferation

The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferation

Association between fine particulate matter chemical constituents and airway inflammation: A panel study among healthy adults in China

Air Pollution alongside Bike-Paths in Bogotá-Colombia

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