Fine particulate matter-induced cardiovascular injury is associated with NLRP3 inflammasome activation in Apo E-/- mice

Du, Xihao; Jiang, Shuo; Zeng, Xianmin; Zhang, Jia; Pan, Kun; Song, Lun; Zhou, Ji; Kan, Haidong; Sun, Qinghua; Zhao, Jingang; Xie, Ying

doi:10.1016/j.ecoenv.2019.02.064

Cited by 46 publications

(26 citation statements)

References 39 publications

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“…A subsequent release enables adjacent epithelial cells to amplify this signal by stimulating the production of IL-1α, TNF-α, and IL-6. PM-induced activation of the inflammasome in the skin has not yet been studied; however in the pulmonary [247] and cardiovascular [248] systems, it was shown that PM activates the NLPR3 inflammasome in vivo (e.g., in mice).…”

Section: Pm-induced Activation Of Nf-κbmentioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

126

116

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Background: Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. Main text: To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health. Conclusion: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.

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Section: Pm-induced Activation Of Nf-κbmentioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

126

116

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“…Particulate matter (PM), and especially its fine fraction (PM 2.5 ), existing in the atmosphere is considered to cause severe and different toxic effects on humans, including respiratory (Kowalska et al, 2019) and cardiovascular diseases (Du et al, 2019), nephrotoxicity (Hsu et al, 2005), diabetes (Lao et al, 2019), fetal distress in pregnant women (Liu et al, 2019), allergy (Dedele et al, 2019), autism (Kaufman et al, 2019), decreased fertility (Xia et al, 2019), and cancer (Santibáñez-Andrade et al, 2017). Eye irritation, dry throat, runny nose, sneezing, cough, tiredness, irritability, difficulty concentrating, headache, dizziness, and skin irritation are other less serious, indeed annoying side effects of human exposure to PM (Nezis et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…If PM is in contact with environmental or physiological solutions, the substances contained in the particles may be released, thus becoming bio-accessible and potentially toxic to living organisms and human tissues. For this reason, a very large number of papers have been or are being published in which the release of selected elements from PM to simulated physiological fluids was investigated (Benetello et al, 2018;Catalani et al, 2018;Dehghani et al, 2018;Gao et al, 2018;Hernández-Pellón et al, 2018;Huang et al, 2018;Kastury et al, 2018a, b;Nie et al, 2018;Pelfrêne and Douay, 2018;Wiseman et al, 2018;Berlinger et al, 2019;Du et al, 2019;Hernández-Pellón et al, 2019;Luo et al, 2019;Tang et al, 2019;Xing et al, 2019). For a list of older references see the review by Mukhtar and Limbeck (2013).…”

Section: Introductionmentioning

confidence: 99%

Metal Ion Release from Fine Particulate Matter Sampled in the Po Valley to an Aqueous Solution Mimicking Fog Water: Kinetics and Solubility

Marco

Tapparo

Badocco

et al. 2020

Aerosol Air Qual. Res.

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Metals are among the key aerosol components exerting adverse health effects. Their toxic properties may vary depending on their chemical form and solubility, which can be affected by aqueous processing during aerosol atmospheric lifetime. In this work, fine particulate matter (PM 2.5) was collected in the city centre of Padua in the Po Valley (Italy), during a winter campaign. Part of the sampling filters were used to measure the kinetics by which metal ions and other elements can leach from PM 2.5 to an aqueous solution mimicking fog water in the winter in temperate climate regions (pH 4.7, 5°C). The leaching process was interpreted by a first order kinetics, and the fitting of the experimental data allowed to obtain the leaching kinetic constants and the equilibrium concentrations (i.e., at infinite time) for all elements. The remaining filter parts were mineralised, through two subsequent extraction steps, and the extracts were analysed by ICP-MS to gain the total elemental content of PM for a large number of elements. We found that elements can leach from PM with half times generally between 10-40 minutes, which is a timescale compatible with atmospheric aqueous processing during fog events. For instance, aluminium(III) in PM 2.5 dissolved with an average k = 0.0185 min-1 , and t 1/2 = 37.5 min. Nevertheless, a fraction of each element was immediately solubilised after contact with the extraction solution suggesting that metal ion solubilisation may already had started during particle lifetime in the atmosphere.

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“…It has been shown in vitro that nanoparticles formed by silica and iron compounds can stimulate macrophages to induce reactive oxygen species (ROS) production, activation of NLRLP3 in ammasome and cytokine release (22)(23)(24). What is more, several studies indicated a strong ability of silica NPs (SiNPs) to differentiate macrophages towards M1 phenotype (25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

The Differences Between Action of Inhaled Silica and Iron Nanoparticles in ApoE-knockout mice – Silica Nanoparticles Exacerbate Atherosclerosis Through Skewing Macrophage Polarization Towards M1 Phenotype

Stachyra¹,

Wiśniewska²,

Kuś³

et al. 2021

Preprint

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Background: Exposure to airborne particulate matter, especially its organic part, is strongly related to the development of cardiovascular disorders including atherosclerosis. The role of inorganic part of air pollution in the pathogenesis of atherosclerosis is still unclear. The aim of this study was to investigate the mechanism of action of two substantial components of inorganic part of airborne particulate matter (SiO2 and Fe2O3) in atherosclerosis. To do this, we used apolipoprotein E-knockout mice exposed to silica (SiNPs) and ferric oxide (FeNPs) nanoparticles in a whole body inhalation chamber for 16 weeks. To our knowledge, this is the first time when whole body exposure system was applied to examine the effects of silica and ferric oxide nanoparticles on atherosclerosis development in mouse model of atherosclerosis. Results: Inhaled silica nanoparticles augmented the atherosclerotic lesions and increased the percentage of pro-inflammatory M1 macrophages in both the plaque and the peritoneum in apoE-/- mice. Exposure to ferric oxide nanoparticles did not enhance atherogenesis process, however, it caused significant changes in the atherosclerotic plaque composition (elevated content of CD68-positive macrophages and enlarged necrotic core accompanied by the decreased level of M1 macrophages). Both silica and iron oxide NPs altered the phenotype of T lymphocytes in the spleen by promoting polarization towards Th17 cells. Conclusions: Exposure to silica and ferric oxide nanoparticles exerts differential impact on atherosclerosis development. Silica nanoparticles enhance atherosclerosis, which is associated with increased level of M1 macrophages, while ferric oxide nanoparticles alter atherosclerotic plaque composition without influencing the size of the lesions.

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Fine particulate matter-induced cardiovascular injury is associated with NLRP3 inflammasome activation in Apo E-/- mice

Cited by 46 publications

References 39 publications

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Metal Ion Release from Fine Particulate Matter Sampled in the Po Valley to an Aqueous Solution Mimicking Fog Water: Kinetics and Solubility

The Differences Between Action of Inhaled Silica and Iron Nanoparticles in ApoE-knockout mice – Silica Nanoparticles Exacerbate Atherosclerosis Through Skewing Macrophage Polarization Towards M1 Phenotype

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