2010
DOI: 10.1002/yea.1791
|View full text |Cite
|
Sign up to set email alerts
|

Fine regulation of Saccharomyces cerevisiae MAPK pathways by post‐translational modifications

Abstract: Saccharomyces cerevisiae has been widely used as a model eukaryotic organism to elucidate the molecular mechanisms that operate upon activation of signalling pathways. For over two decades, many clues to the regulation of mitogen-activated protein kinase (MAPK) pathways have derived from basic research in yeast. Here we review aspects of MAPK pathway fine-tuning, such as the functional implication of feedback loops or regulatory inputs from other pathways, mediated by post-transcriptional modifications on thei… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
30
0

Year Published

2010
2010
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 32 publications
(30 citation statements)
references
References 66 publications
(70 reference statements)
0
30
0
Order By: Relevance
“…The abundance of the enzymes is the result of numerous molecular processes taking place from the transcriptional to the translational level, including epigenetic modifications of the DNA and chromatin (4), transcriptional regulation by transcription factors (5), mRNA capping and splicing and small RNA regulation (6), protein turnover (7), etc. The enzyme activation state is primarily because of post-translational modifications of the native protein, themselves highly regulated (8,9). Other mechanisms involved in enzyme activity are proteinprotein interactions and allosteric regulation, such mechanisms being sometimes mediated through post-translational modifications (10,11).…”
mentioning
confidence: 99%
“…The abundance of the enzymes is the result of numerous molecular processes taking place from the transcriptional to the translational level, including epigenetic modifications of the DNA and chromatin (4), transcriptional regulation by transcription factors (5), mRNA capping and splicing and small RNA regulation (6), protein turnover (7), etc. The enzyme activation state is primarily because of post-translational modifications of the native protein, themselves highly regulated (8,9). Other mechanisms involved in enzyme activity are proteinprotein interactions and allosteric regulation, such mechanisms being sometimes mediated through post-translational modifications (10,11).…”
mentioning
confidence: 99%
“…Many regulatory mechanisms modulate signaling through MAPK pathways in yeast (Chen and Thorner, 2005;Molina et al, 2010;Zeke et al, 2009). These mechanisms include scaffold proteins and docking interactions that contribute to providing signaling specificity and the prevention of improper crosstalk (Flatauer et al, 2005;Saito and Posas, 2012;Witzel et al, 2012;Zalatan et al, 2012), protein phosphatases that directly dephosphorylate protein kinases to attenuate the response when necessary (Martín et al, 2005), and positive-and negative-feedback circuits (FBLs), which are required to maintain a balanced output in the stimuli response (Mobashir et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…These mechanisms include scaffold proteins and docking interactions that contribute to providing signaling specificity and the prevention of improper crosstalk (Flatauer et al, 2005;Saito and Posas, 2012;Witzel et al, 2012;Zalatan et al, 2012), protein phosphatases that directly dephosphorylate protein kinases to attenuate the response when necessary (Martín et al, 2005), and positive-and negative-feedback circuits (FBLs), which are required to maintain a balanced output in the stimuli response (Mobashir et al, 2014). Feedback mechanisms are mainly exerted through post-translational modifications, such as phosphorylation events performed by the MAPK on upstream elements of the pathway (retrophosphorylation) (Feng and Davis, 2000;Flotho et al, 2004;Hao et al, 2007;Kranz et al, 1994;Molina et al, 2010;Saito and Posas, 2012). Alternatively to phosphorylation regulatory mechanisms, regulatory circuits can be based on the transcriptional regulation of their own elements, either inactivators (negative feedback) or activators ( positive feedback) (Molina et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Other modifications, such as sumoylation, glycosylation, acylation, lipidation, and ubiquitination are also emerging as regulators of cell signaling (16,17).…”
mentioning
confidence: 99%