Fine Structure of Bowen's Disease in Chronic Arsenicalism2

Yeh, Shu; Chen, H.C.; How, Shu-Wen; Deng, C.S.

doi:10.1093/jnci/53.1.31

Cited by 16 publications

(3 citation statements)

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“…We found no significant widening of the intercellular space in carcinomas, in contrast to Frithiof (I 972), and also found a variety of inflammatory cells in the space in carcinomas, but not in normal oesophageal epithelium. Most authors report a decrease in number of desmosomes in squamous carcinoma and some of the desmosomes which remain may be intracellular (Yeh et al, 1974). We did not find any significant alteration in desmosome numbers or sites.…”

Section: His Tochemical Jindingscontrasting

confidence: 64%

Oesophageal neoplasia in male wistar rats due to parenteral di(2‐hydroxypropyl)nitrosamine (DHPN): A combined histopathological, histochemical and electron microscopic study

Levison

Hopwood

Morgan

et al. 1979

The Journal of Pathology

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Intraperitoneal di(2-hydroxypropyl)-Nitrosamine (DHPN) caused a high incidence of oesophageal squamous carcinoma in male Wistar rats, particularly in rats killed 11 or more months after the start of injections. No control rats (injected intraperitoneally with saline) developed an oesophageal neoplasms. Histopathologically, the tumours were moderately well differentiated. Histochemical studies showed minor increases in mucin staining and mast cell population and a marked increase in bacteria in tumour-bearing oesophaguses. Electron microscopy showed the tumours to be similar to, but to differ in some respects from squamous carcinomas at other sites in humans. The possible implications of this work for human disease are twofold. It could provide a model for further study of aspects of oesophageal carcinoma and it serves to remind us that all potential oesophageal carcinogens need not act during swallowing.

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Section: His Tochemical Jindingscontrasting

confidence: 64%

Oesophageal neoplasia in male wistar rats due to parenteral di(2‐hydroxypropyl)nitrosamine (DHPN): A combined histopathological, histochemical and electron microscopic study

Levison

Hopwood

Morgan

et al. 1979

The Journal of Pathology

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“…That arsenic ingestion might lead to BD was suggested as early as 1961 by Graham et al (48). It had also been reported by several other groups such as Imamura et al (49) and Yeh et al (50,51). Arsenic-induced BD has been reported sporadically from several populations including Japanese (49,(52)(53)(54)(55), Japanese-American population in Hawaii (56), Thai (57), Taiwan (58,59), Finlandnish (60), Turkey (61,62), Korea (63,64), West Bengal, India (65)(66)(67), Nepal (68) and South Africa (69).…”

Section: Arsenic-induced Skin Cancerssupporting

confidence: 59%

Arsenic-induced Cancers: A Review with Special Reference to Gene, Environment and Their Interaction

Banerjee

Bhattacharjee

Giri

2011

Genes and Environment

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Chronic exposure to the toxic metalloid arsenic, either through occupational or environmental route results in the development of a plethora of dermatological as well as non-dermatological health eŠects, multi-organ cancers being the most severe ones. Several epidemiological studies have reported the occurrence of diŠerent types of cancers in populations exposed chronically to arsenic from diŠerent corners of the globe, but the spectrum of symptoms and severity vary widely. Several genetic and environmental factors might play an important causal role for such observed diŠerences, including genetic polymorphisms, dietary habits and socioeconomic status of the population. Unfortunately, the paradoxical nature of this carcinogen makes the use of animal model systems unsuitable, since they do not re‰ect the exact in vivo condition of arsenic exposure in human beings. Hence, in this present review, we have attempted to collate the isolated pieces of information available in existing literature depicting the various forms of arsenic-induced cancers, variations and etiology thereof. We have attempted to depict the entire spectrum of carcinogenic outcomes of chronic arsenic exposure and the interactions among several components like, genes (polymorphisms and mutations), environmental factors and dietary factors in the process. The literature reviews are primarily based on the human beings (in vivo), but to understand the underlying mechanism, we have also collated the information based on cell line models, and animal models where human data is scanty or unavailable. Thus, here we present a comprehensive review on the current state of research in theˆeld of arsenic-induced cancer and explore the underlying mechanism of arsenic-induced carcinogenicity, along with relevant historical perspective.

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“…Histopathologically, various patterns like psoriasiform, verrucous, pagetoid, hyperkeratotic, atrophic, and pigmented have been mentioned [10]. Numerous vacuolated atypical cells may be seen in arsenical BD [1, 25]. Pagetoid variant of BD is sometimes difficult to distinguish from Paget's disease and from in-situ superficial spreading melanoma [10].…”

Section: Discussionmentioning

confidence: 99%

Multiple Pigmented Bowen’s Disease: A Diagnostic and Therapeutic Dilemma

Gahalaut

Rastogi

Mishra

et al. 2012

Case Reports in Oncological Medicine

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Bowens' disease (BD) is a precancerous condition of skin and/or mucosa with a predilection towards sun-exposed areas. Extensive literature research failed to reveal any case of multiple pigmented BD in type V Fitzpatrick skin. Multiple BD is a therapeutic challenge with a tendency to recur. Here we present an otherwise healthy Indian male having multiple pigmented lesions of BD on sun-protected sites of the body mimicking malignant melanoma. These lesions were refractory to treatment with different modalities. This paper is an attempt to review the available literature regarding the pigmented variant of multiple BD. Rationale for a therapeutic trial of UVB therapy for multiple arsenic induced BD is also discussed.

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Fine Structure of Bowen's Disease in Chronic Arsenicalism2

Cited by 16 publications

References 0 publications

Oesophageal neoplasia in male wistar rats due to parenteral di(2‐hydroxypropyl)nitrosamine (DHPN): A combined histopathological, histochemical and electron microscopic study

Oesophageal neoplasia in male wistar rats due to parenteral di(2‐hydroxypropyl)nitrosamine (DHPN): A combined histopathological, histochemical and electron microscopic study

Arsenic-induced Cancers: A Review with Special Reference to Gene, Environment and Their Interaction

Multiple Pigmented Bowen’s Disease: A Diagnostic and Therapeutic Dilemma

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