Fine Structure of Eccrine Sweat Gland Adenoma, Clear Cell Type

Nodular Hidradenoma

“…Nodular hidradenoma (NH) is an adnexal tumor known under various other names such as clear cell myoepithelioma, 1 clear cell hidradenoma, 2 solid cystic hidradenoma, 3 eccrine acrospiroma, 4 and eccrine sweat gland adenoma of clear cell type 5 . NH is generally regarded as a tumor of eccrine origin on the basis of its enzyme histochemistry and electron microscopy features.…”

Cutaneous Clear Cell Neoplasms

“…68 Other names include eccrine acrospiroma, 69 clear cell myoepithelioma, 70 solid cystic hidradenoma, 71 and eccrine sweat gland adenoma of clear cell type. 72 Less than a third of cases show a preponderance of clear cells thereby arbitrarily qualifying as clear cell hidradenoma (CCH). 71 Clinically, most cases of CCH present as a solitary slow growing nodule with histopathologic features that include a multilobulated, well circumscribed, intradermal, solid-cystic epithelial proliferation, with or without an epidermal connection, and clear cell and ductal differentiation (Figs.…”

Malignant clear cell hidradenoma of the upper lip

“…It is the malignant variant of the more common clear cell hidradenoma which is also currently termed ec-crine acrospiroma,2 solid cystic hidraden~ma,~ and eccrine sweat gland adenoma of the clear cell type. 4 Both benign and malignant clear cell hidradenomas present as firm, solitary, painless intradermal nodules. They are usually covered by intact skin that ranges from pink to purple or blue and some may have surface ulceration^.^'^^^ Because of their relatively nondescript appearance, these tumors are rarely diagnosed clinically.6 The differential diagnosis encompasses a large number of benign and malignant skin neoplasms, including hemangioma, lymphangioma, squamous cell carcinoma, basal cell carcinoma, dermatofibrosarcoma, granuloma pyogenicum, blue nevus, and malignant melanoma.…”