Fine Structure of Senile Angiomas of Human Skin

Stehbens, William E.; Ludatscher, Ruth M.

doi:10.1177/000331976801901002

Cited by 30 publications

(14 citation statements)

References 34 publications

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“…A distinctive common feature of all these vessels was the presence of a multilaminated basal lamina [2,43,46]. In addition, however, we found a pronounced thickening of the vascular wall around many of the cherry haemangioma vessels, corroborating the findings of Braverman and Keh-Yen [2].…”

Section: Discussionsupporting

confidence: 89%

“…The cherry h a e m a n g i o m a s investigated in this study showed the typical histological characteristics described [2,23,41,43]. In small lesions, most of the capillaries were narrow and lined by prominent endothelial cells.…”

Section: Light Microscopysupporting

confidence: 61%

“…The capillaries of cherry haemangiomas showed similar ultrastructural characteristics, such as dilated venous capillaries of postcapillary venules, to normal human skin [2,43]. A distinctive common feature of all these vessels was the presence of a multilaminated basal lamina [2,43,46].…”

Section: Discussionmentioning

confidence: 90%

“…It has been suggested that the sheath material comprises 'degenerated' or 'homogenized" collagen [23,41], but its nature and origin are still unclear. Electronmicroscopically, multilaminated basement membrane-like material [2,43], thin collagen or 'reticulin' fibres [2,43] and zebra bodies or fibrous long-spacing fibres [2] have been observed around cherry haemangioma capillaries.…”

mentioning

confidence: 99%

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Increase in types IV and VI collagen in cherry haemangiomas

Tamm

Jungkunz

et al. 1992

Arch Dermatol Res

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Summary. The capillaries in cherry haemangiomas show perivascular hyalinized sheaths. In order to clarify the nature of this sheath material, the extracellular matrix of cherry haemangiomas from 20 normal volunteers (age range 30-64 years) was investigated using immunohistochemical and electronmicroscopical methods. Antibodies against collagen types III, IV and VI and laminin were used. Hyaluronic acid was visualized using the hyaluronic acid binding region of the cartilage proteoglycan as ligand. Electronmicroscopically, the sheaths contained multilaminated basement membrane-like material, collagen fibres 20-25 nm thick with a periodicity of 67 nm and broadbanded aggregates with a periodicity of 100 nm (zebra bodies or fibrous long-spacing fibres). Immunohistochemically, type IV collagen was stained throughout the whole sheath material. Staining for laminin was more confined to the endothelial side of the sheath. Intense staining for type III collagen and hyaluronic acid was found in the connective tissue of the subpapillary layer and between the cherry haemangioma capillaries. Much weaker staining for type III coUagen and no staining for hyaluronic acid were found invariably in an area 4-10 [tm thick directly around the capillaries. Both sheath material and intercapillary connective tissue of the haemangiomas showed pronounced staining for collagen type VL Immunogold staining revealed that type VI collagen was localized to microfihrils 5-6 nm thick and to the broad-banded aggregates with 100 nm periodicity. These findings further underline the assumption that the broad-banded aggregates consist of type VI collagen.

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Section: Discussionsupporting

confidence: 89%

Section: Light Microscopysupporting

confidence: 61%

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

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Increase in types IV and VI collagen in cherry haemangiomas

Tamm

Jungkunz

et al. 1992

Arch Dermatol Res

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“…The results of pertinent laboratory studies are as follows: complete blood cell count, within normal limits; platelets, 256,000/cu mm; total protein, 7.2 gm/100 ml; albumin, 4.5 gm/100 ml; total bilirubin, 0.5 mg/100 ml; alkaline phosphatase, 93 milliunits/ml (normal, 30 to 85); serum glutamic oxaloacetic transaminase, 53 milliunits/ml; serum glutamic pyruvic transaminase, 20 milliunits/ml; sulfobromophthalein, 449Í; prothrombin time, 90%; 24-hour urine 17-Ketosteroids, 6 Right brachial arteriography revealed very slow filling of the arteries of the hand and of the fingers. Demonstrable vessel spasm was absent.…”

mentioning

confidence: 99%