Fine structure of the seminiferous tubule of the swiss mouse. The spermatid

Gardner, Paul J.

doi:10.1002/ar.1091550210

Cited by 45 publications

(26 citation statements)

References 13 publications

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“…Centrally moving mitochondria can then form the mitochondrial sheath characteristic of the definitive midpiece. This occurs in the cat (present report) as in other mammals (Gardner, 1966;Phillips, 1980). During cat spermiogenesis, two different shapes of mitochondria were observed.…”

Section: Discussionsupporting

confidence: 73%

Disposition of the manchette and related events in the feline spermatid

Sickels

Heath

1986

Anat. Rec.

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The manchette is a transient microtubular organelle previously considered to "disappear" prior to formation of the definitive midpiece of the spermatozoon. Goodrowe and Heath (1984) have suggested, however, that in stallions the final disposition of the microtubules of the manchette is into the residual cytoplasm. In the present study, spermiogenesis was examined by transmission electron microscopy of testicular samples from eight cats. Feline spermatids also had a manchette of cylindrical shape, largely located in a cytoplasmic collar peripheral to the presumptive midpiece. The parallel microtubules of the manchette were interconnected by arms. Some of these arms were still present after rupture of the manchette cylinder and movement of the microtubules into the residual cytoplasm. On displacement of the manchette microtubules, mitochondria, spherical in shape and peripherally located, moved centrally to elongate and encircle the flagellum to form the definitive midpiece.

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Section: Discussionsupporting

confidence: 73%

Disposition of the manchette and related events in the feline spermatid

Sickels

Heath

1986

Anat. Rec.

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“…In the mouse, Oakberg (1956) proposed 12 stages, whereas dog spermatogenesis was redefined by Russell et al (1990) into eight stages. The use of resin-embedded materials sectioned to 1 µm or less and electron microscopy allowed other authors to reexamine the staging schemes in diverse species (Gardner and Holyoke, 1964;Gardner, 1966;Lalli, 1972;Ulvik et. al., 1982).…”

Section: Discussionmentioning

confidence: 99%

Stages of the cycle of the seminiferous epithelium of the Viscacha (Lagostomus maximus maximus)

Muñoz¹,

Fogal²,

Domínguez³

et al. 1998

Anat. Rec.

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The adult male viscacha (Lagostomus maximus maximus) is a seasonal rodent. It exhibits a short period of testicular regression with partial arrest of spermatogenesis during winter (July-August). The present study provides the first description of the viscacha spermatogenic cycle during the period of maximum gonadal activity (summer-autumn).The testes were processed by using conventional techniques of light and electron microscopy. One-micrometer-thick sections stained with toluidine blue were used to clearly define the different cell associations.Spermatogenesis in this rodent is well organized and synchronized and has been divided into nine stages. The present classification is based on the morphogenesis of the acrosomal system (stages I-V) and the degree of elongation and condensation of the heads of the differentiating spermatids (stages VI-IX). Stage I is principally defined by round spermatids with a well-developed, juxtanuclear Golgi complex and without acrosomal components that are visible under the light microscope. Sperm release from the viscacha seminiferous epithelium occurs either in late stage III or in early stage IV. Stage IX is characterized by diplotene spermatocytes, figures of meiosis I or II, and secondary spermatocytes. Anat.

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“…This is followed by the release of fully developed spermatids from Sertoli cells, referred to as spermiation, and the acquisition of fertilizing capacity during transit of the maturing spermatozoa through the epididymis (Clermont, 1972;Gardner, 1966). Transcriptional silencing of the haploid genome, by histoneto-protamine transition and chromatin compaction, precedes the final steps of spermiogenesis when ongoing protein synthesis depends on stability of mRNAs and developmental control of their translation (Kleene, 1993;Yang et al, 2005;Zhong et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases

Shang

Baarends

Hoogerbrugge

et al. 2010

Journal of Cell Science

116

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SummaryThe cytoplasmic chromatoid body (CB) organizes mRNA metabolism and small regulatory RNA pathways, in relation to haploid gene expression, in mammalian round spermatids. However, little is known about functions and fate of the CB at later steps of spermatogenesis, when elongating spermatids undergo chromatin compaction and transcriptional silencing. In mouse elongating spermatids, we detected accumulation of the testis-specific serine/threonine kinases TSSK1 and TSSK2, and the substrate TSKS, in a ring-shaped structure around the base of the flagellum and in a cytoplasmic satellite, both corresponding to structures described to originate from the CB. At later steps of spermatid differentiation, the ring is found at the caudal end of the newly formed mitochondrial sheath. Targeted deletion of the tandemly arranged genes Tssk1 and Tssk2 in mouse resulted in male infertility, with loss of the CB-derived ring structure, and with elongating spermatids possessing a collapsed mitochondrial sheath. These results reveal TSSK1-and TSSK2-dependent functions of a transformed CB in post-meiotic cytodifferentiation of spermatids.

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Fine structure of the seminiferous tubule of the swiss mouse. The spermatid

Cited by 45 publications

References 13 publications

Disposition of the manchette and related events in the feline spermatid

Disposition of the manchette and related events in the feline spermatid

Stages of the cycle of the seminiferous epithelium of the Viscacha (Lagostomus maximus maximus)

Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases

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