Fine structure of the vertebrate Z-disc

Ullrick, William C.; Toselli, Paul; Saide, Judith D.; Phear, W. P. C.

doi:10.1016/0022-2836(77)90246-7

Cited by 30 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous investigation, we found similar morphological changes in the m.soleus after a regimen involving running downstairs (16). In the Z-band, the facing sarcomere actin filaments are connected in a complicated manner (21,30,36). The links between sarcomeres connected in series, that is the Z-disks, are subjected to repeated stretching during eccentric work and seem to constitute the myofibrillar part that is most prone to mechanically induced damage.…”

Section: Semithin Sectionsmentioning

confidence: 59%

Myofibrillar Damage Following Intense Eccentric Exercise in Man

Fridén¹,

Sjöstróm²,

Ekblom³

1983

Int J Sports Med

887

590

View full text Add to dashboard Cite

Section: Semithin Sectionsmentioning

confidence: 59%

Myofibrillar Damage Following Intense Eccentric Exercise in Man

Fridén¹,

Sjöstróm²,

Ekblom³

1983

Int J Sports Med

887

590

View full text Add to dashboard Cite

“…The observation of up to four cross connections joining to the axial filament within 5 nm is consistent with observations from electron micrographs of cross sections. Such observations reveal from zero to four cross-connecting filaments joining to each axial filament in projection images (Ullrick et al, 1977;Goldstein et al, 1982;Yamaguchi et al, 1985). However, the F-actin core of the axial filament presents at most two actin monomers in this short distance.…”

Section: Discussionmentioning

confidence: 92%

Three-dimensional structure of the Z band in a normal mammalian skeletal muscle.

Schroeter

Bretaudiere

Sass

et al. 1996

The Journal of Cell Biology

View full text Add to dashboard Cite

Abstract. The three-dimensional structure of the vertebrate skeletal muscle Z band reflects its function as the muscle component essential for tension transmission between successive sarcomeres. We have investigated this structure as well as that of the nearby I band in a normal, unstimulated mammalian skeletal muscle by tomographic three-dimensional reconstruction from electron micrograph tilt series of sectioned tissue.The three-dimensional Z band structure consists of interdigitating axial filaments from opposite sarcomeres connected every 18 _+ 12 nm (mean _+ SD) to one to four cross-connecting Z-filaments. Most often, the cross-connecting Z-filaments are observed to meet the axial filaments in a fourfold symmetric arrangement. The substantial variation in the spacing between cross-connecting Z-filament to axial filament connection points suggests that the structure of the Z band is not determined solely by the arrangement of a-actinin to actin-binding sites along the axial filament. The cross-connecting filaments bind to or form a "relaxed interconnecting body" halfway between the axial filaments. This filamentous body is parallel to the Z band axial filaments and is observed to play an essential role in generating the small square lattice pattern seen in electron micrographs of unstimulated muscle cross sections. This structure is absent in cross sections of the Z band from muscles fixed in rigor or in tetanus, suggesting that the Z band lattice must undergo dynamic rearrangement concomitant with crossbridge binding in the A band.

show abstract

“…Ullrick et al . (21) have proposed a model in which three strands from axial filaments of the same sarcomere generate the lattice seen in crosssectional projections . We consistently see fourfold or twofold symmetry in cross sections, independent of section thickness.…”

Section: Discussionmentioning

confidence: 99%

The Z lattice in canine cardiac muscle.

Goldstein¹,

Schroeter²,

Sass³

1979

The Journal of Cell Biology

View full text Add to dashboard Cite

Filtered images of mammalian cardiac Z bands were reconstructed from optical diffraction patterns from electron micrographs . Reconstructed images from longitudinal sections show connecting filaments at each 38-nm axial repeat in an array consistent with cross-sectional data . Some reconstructed images from cross sections indicate two distinctly different optical diffraction patterns, one for each of two lattice forms (basket weave and small square) . Other images are more complex and exhibit composite diffraction patterns . Thus, the two lattice forms co-exist, interconvert, or represent two different aspects of the same details within the lattice . Two three-dimensional models of the Z lattice are presented . Both include the following features : a double array of axial filaments spaced at 24 nm, successive layers of tetragonally arrayed connecting filaments, projected fourfold symmetry in cross section, and layers of connecting filaments spaced at intervals of 38 nm along the myofibril axis . Projected views of the models are compared to electron micrographs and optically reconstructed images of the Z lattice in successively thicker cross sections . The entire Z band is rarely a uniform lattice regardless of plane of section or section thickness . Optical reconstructions strongly suggest two types of variation in the lattice substructure : (a) in the arrangement of connecting filaments, and (b) in the arrangement of units added side-to-side to make larger myofilament bundles and/or end-to-end to make wider Z bands . We conclude that the regular arrangement of axial and connecting filaments generates a dynamic Z lattice . KEY WORDS cardiac muscle -Z bands optical diffraction -image reconstructionIn canine cardiac muscle the Z band in longitudinal section varies in width from 80 to 160 nm and is a repeating filamentous structure with associated electron-dense material at the edge of each sarcomere. In cross sections the Z band is delineated from the surrounding sarcoplasm by vesicles of the sarcoplasmic reticulum (2), and the Z band has a repeating tetragonal unit cell (6). At J. CELL BIOLOGY

show abstract

Fine structure of the vertebrate Z-disc

Cited by 30 publications

References 13 publications

Myofibrillar Damage Following Intense Eccentric Exercise in Man

Myofibrillar Damage Following Intense Eccentric Exercise in Man

Three-dimensional structure of the Z band in a normal mammalian skeletal muscle.

The Z lattice in canine cardiac muscle.

Contact Info

Product

Resources

About