Fine-tuning blastocyst selection based on morphology: a multicentre analysis of 2461 single blastocyst transfers

Storr, Ashleigh; Bilir, Esra; Cooke, Stephen A.; Garrett, Don; Venetis, Christos A.

doi:10.1016/j.rbmo.2019.06.008

Cited by 11 publications

(11 citation statements)

References 42 publications

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“…The degree of blastocoel expansion was signi cantly correlated with the success rate of ART. The probability of live birth with expanded and hatching blastocysts was signi cantly higher than that of early and fully expanded blastocysts [5]. The re-expansion rate of frozen-thawed blastocysts was signi cantly positively correlated with the clinical pregnancy rate [27].…”

Section: Discussionmentioning

confidence: 90%

“…However, there are few reports on the relationship between the degree of blastocoel expansion and neonatal outcomes. To our knowledge, only two articles have reported that the degree of blastocyst expansion had no signi cant correlation with birthweight and neonatal outcomes [4,5]. Given the contradiction between blastocyst quality and birthweight, neonatal outcomes, our study, which included the largest sample size of newborns, evaluated the effects of all blastocyst quality indicators, including developmental stage, degree of blastocoel expansion, and ICM/TE morphology on birthweight and adverse neonatal outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy complications that signi cantly affected birthweight (gestational diabetes, gestational hypertension, preeclampsia), monozygotic twin births, and a history of pre-implantation cycles were excluded. For the transfer of fresh blastocysts, good quality blastocysts were de ned as ≥3-6BB, poor quality blastocysts were de ned as 3-6BC/CB, and early blastocysts (stage 1 or 2) [5]. There were 494 singletons in the good quality blastocyst group and 123 singletons in the poor quality blastocyst group.…”

Section: Participantsmentioning

confidence: 99%

“…According to the size of the blastocyst cavity and the signs of hatching or not, blastocyst development was divided into six stages. In stage 3-6 blastocysts, the ICM/TE morphology is assessed from grade A to C. Several studies have reported that there is a strong correlation between blastocyst quality, developmental stage (day 5 vs. day 6), and live birth rate [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Transfer of hatched blastocyst can result in skewed sex ratio: a retrospective cohort study

Zhu¹,

Lian²,

Zhuang³

et al. 2021

Preprint

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Background The correlation between blastocyst quality and birthweight, neonatal outcomes is still controversial. There is a significantly higher male: female ratio among good quality blastocysts (advanced trophoderm morphology) but in the expansion degree, the significance for sex ratio is unclear. Methods A total of 617 and 6803 live singleton births resulting from the transfer of fresh and frozen-thawed single blastocysts in the Reproductive Medicine Center of Peking University Third Hospital from 2009 to 2020 were included. Live singleton births from fresh and frozen-thawed single blastocyst transfer were stratified by inner cell mass/trophoderm morphology and degree of blastocoel expansion. Multivariate linear regression was used to analyze the correlation between expansion, inner cell mass/trophoderm morphology, and birthweight, Z score, gestational weeks. Logistic regression was used to analyze the relationship between expansion, ICM/TE morphology and sex, neonatal outcomes. Results There was no significant correlation between birthweight, neonatal outcomes and blastocyst quality in fresh and frozen-thawed single blastocyst transfer cycles. However, the proportion of male infants in the hatched blastocyst (stage-6) group (67.9% vs. 54.2%; p < 0.001) [OR: 1.76 95% CI (1.34–2.32)] and hatching blastocyst (stage-5) group (61.7% vs. 54.2%; p = 0.001) [OR: 1.36 95 C.I (1.14ཞ1.62)] was significantly higher than that in the expanded blastocyst (stage-4) group. Conclusions The transfer of poor-quality blastocysts is unlikely to affect birthweight and neonatal health; however, transfer of stage-6 blastocysts can result in extremely skewed sex ratio.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transfer of hatched blastocyst can result in skewed sex ratio: a retrospective cohort study

Zhu¹,

Lian²,

Zhuang³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Reproductive outcomes following IVF treatment are impacted by the developmental stage and rate of the transferred embryo. Day 5 (D5) embryo transfer is more successful when the transferred embryo is at the hatching, expanded or full blastocyst stage compared to the morula or early blastocyst stage, even when controlling for female age and endometrial receptivity (Gardner et al 2000, Storr et al 2019. With the advent of vitrification and improvements in frozen embryo transfer (FET) outcomes, extended culture of slowly developing embryos until blastulation on Day 6 (D6) has become a more standard practice in embryology laboratories.…”

Section: Introductionmentioning

confidence: 99%