2021
DOI: 10.3390/gels7030134
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Fine-Tuning of Molecular Structures to Generate Carbohydrate Based Super Gelators and Their Applications for Drug Delivery and Dye Absorption

Abstract: Carbohydrate-based low molecular weight gelators (LMWGs) exhibit many desirable properties making them useful in various fields including applications as drug delivery carriers. In order to further understand the structural connection to gelation properties, especially the influence of halide substitutions, we have designed and synthesized a series of para-chlorobenzylidene acetal protected D-glucosamine amide derivatives. Fifteen different amides were synthesized, and their self-assembling properties were ass… Show more

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Cited by 12 publications
(8 citation statements)
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“…The self-assembling characteristics of these amides were examined in a variety of solvents, organics as well as mixtures, which revealed the property of these derivatives to form gels at low minimum gelation concentrations (MGCs) even below 0.1 wt%. The exploration resulted in the formation of a highly stable gel in water and EtOH/H 2 O by a gelator 128 benzamide 105 (Fig. 65) at an extremely low concentration of 0.04 wt%.…”
Section: New Carbohydrate-based Gelatorsmentioning
confidence: 99%
“…The self-assembling characteristics of these amides were examined in a variety of solvents, organics as well as mixtures, which revealed the property of these derivatives to form gels at low minimum gelation concentrations (MGCs) even below 0.1 wt%. The exploration resulted in the formation of a highly stable gel in water and EtOH/H 2 O by a gelator 128 benzamide 105 (Fig. 65) at an extremely low concentration of 0.04 wt%.…”
Section: New Carbohydrate-based Gelatorsmentioning
confidence: 99%
“…Organogels have been explored as media for the controlled release of drugs for some time. [33][34][35][36] This application can be attributed to the fact that as smart materials organogels are responsive to various stimuli which can be used to trigger the release of the entrapped drugs. Such applications are mainly restricted to organogels of amino acids [37][38][39][40] and peptides, 41 phospholipids, 42 fatty acids 43 and their derivatives, 44 steroids 45 and alkylamides.…”
Section: Entrapment Of Curcumin In Oragnogels and Characterization Of...mentioning
confidence: 99%
“…Biomacromolecular assemblies have received considerable attention recently in the field of biomaterials [1][2][3][4][5][6][7], among which peptides are of particular interest because of their unique merits, such as ease of design and tailoring (based on the known structures from proteins), good biocompatibility and degradability, and low immunogenicity. For example, recent works have demonstrated the potential of peptide assemblies for a wide range of applications, including drug delivery [8][9][10][11], collagen mimic [12], antibacterial [13,14], biomineralization [15,16], mimicry of amyloids [17], cell cultures [18], and tissue engineering [19].…”
Section: Introductionmentioning
confidence: 99%