2024
DOI: 10.1021/acssynbio.4c00102
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Fine-Tuning Pyridoxal 5′-Phosphate Synthesis in Escherichia coli for Cadaverine Production in Minimal Culture Media

Cunping Liu,
Cong Gao,
Longfei Song
et al.

Abstract: Cadaverine is a critical C5 monomer for the production of polyamides. Pyridoxal 5′-phosphate (PLP), as a crucial cofactor for the key enzyme lysine decarboxylase in the cadaverine biosynthesis pathway, has seen a persistent shortage, leading to limitations in cadaverine production. To address this issue, a dual-pathway strategy was implemented, synergistically enhancing both endogenous and heterologous PLP synthesis modules and resulting in improved PLP synthesis. Subsequently, a growth-stage-dependent molecul… Show more

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