Finger tapping and pre-attentive sensorimotor timing in adults with ADHD

Hove, Michael J.; Gravel, Nickolas; Spencer, Rebecca M. C.; Valera, Eve M.

doi:10.1007/s00221-017-5089-y

Cited by 24 publications

(18 citation statements)

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“…These FI changes are further notable given that they could be reflective of impulsivity and or inability to inhibit responding. All of these are features of neurodevelopmental disorders such as autism spectrum disorder and attention deficit hyperactivity disorder (Coghill et al 2014;Hove et al 2017;Lambrechts et al 2018;López-Martín et al 2015;Rubia et al 2009;van Hulst et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice

Sobolewski

Abston

Conrad

et al. 2020

Environ Health Perspect

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BACKGROUND: Lead (Pb) exposure and prenatal stress (PS) during development are co-occurring risk factors with shared biological substrates. PS has been associated with transgenerational passage of altered behavioral phenotypes, whereas the transgenerational behavioral or biochemical consequences of Pb exposure, and modification of any such effects by PS, is unknown. OBJECTIVES: The present study sought to determine whether Pb, PS, or combined Pb and PS exposures produced adverse transgenerational consequences on brain and behavior. METHODS: Maternal Pb and PS exposures were carried out in F0 mice. Outside breeders were used at each subsequent breeding, producing four F1-F2 lineages: [F1 female-F2 female (FF), FM (male), MF, and MM]. F3 offspring were generated from each of these lineages and examined for outcomes previously found to be altered by Pb, PS, or combined Pb and PS in F1 offspring: behavioral performance [fixed-interval (FI) schedule of food reward, locomotor activity, and anxiety-like behavior], dopamine function [striatal expression of tyrosine hydroxylase (Th)], glucocorticoid receptor (GR) and plasma corticosterone, as well as brain-derived neurotrophic factor (BDNF) and total percent DNA methylation of Th and Bdnf genes in the frontal cortex and hippocampus. RESULTS: Maternal F0 Pb exposure produced runting in F3 offspring. Considered across lineages, F3 females exhibited Pb-related alterations in behavior, striatal BDNF levels, frontal cortical Th total percentage DNA methylation levels and serum corticosterone levels, whereas F3 males showed Pb-and PS-related alterations in behavior and total percent DNA methylation of hippocampal Bdnf. However, numerous lineage-specific effects were observed, most of greater magnitude than those observed across lineages, with outcomes differing by F3 sex. DISCUSSION: These findings support the possibility that exposures of previous generations to Pb or PS may influence the brain and behavior of future generations. Observed changes were sex-dependent, with F3 females showing multiple changes through Pb-exposed lineages. Lineage effects may occur through maternal responses to pregnancy, altered maternal behavior, epigenetic modifications, or a combination of mechanisms, but they have significant public health ramifications regardless of mechanism. https://doi.

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Section: Discussionmentioning

confidence: 99%

Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice

Sobolewski

Abston

Conrad

et al. 2020

Environ Health Perspect

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“…We have chosen to consider ADHD in particular because in addition to the core symptoms of inattention and/or hyperactivity/impulsivity, ADHD is also characterized by deficits in motor and perceptual timing (Smith et al, 2002 ; Fair et al, 2012 ; Zelaznik et al, 2012 ; Demers et al, 2013 ; Noreika et al, 2013 ). Recent studies have revealed rhythm-related deficits in ADHD (Hove et al, 2017 ; Puyjarinet et al, 2017 ), and much of the same neural infrastructure that supports the processing of musical rhythm is implicated in ADHD, from brain circuitry (Silk et al, 2009 ; Silberstein et al, 2016 ; Mueller et al, 2017 ) and neural dynamics (Başar and Güntekin, 2008 ; Mazaheri et al, 2014 ; Loo et al, 2017 ) to dopamine signaling, with leading genetic risk factors for ADHD including dopamine gene variants (Swanson et al, 2000 ; DiMaio et al, 2003 ). Here, we propose that insights from research on musical rhythm could offer a more nuanced understanding of timing deficits in ADHD, and potentially lead to the identification of informative phenotypes, linked to neurobiological and genetic factors.…”

Section: Introductionmentioning

confidence: 99%

Timing Deficits in ADHD: Insights From the Neuroscience of Musical Rhythm

Slater

Tate

2018

Front. Comput. Neurosci.

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Everyday human behavior relies upon extraordinary feats of coordination within the brain. In this perspective paper, we argue that the rich temporal structure of music provides an informative context in which to investigate how the brain coordinates its complex activities in time, and how that coordination can be disrupted. We bring insights from the neuroscience of musical rhythm to considerations of timing deficits in Attention Deficit/Hyperactivity Disorder (ADHD), highlighting the significant overlap between neural systems involved in processing musical rhythm and those implicated in ADHD. We suggest that timing deficits warrant closer investigation since they could lead to the identification of potentially informative phenotypes, tied to neurobiological and genetic factors. Our novel interdisciplinary approach builds upon recent trends in both fields of research: in the neuroscience of rhythm, an increasingly nuanced understanding of the specific contributions of neural systems to rhythm processing, and in ADHD, an increasing focus on differentiating phenotypes and identifying distinct etiological pathways associated with the disorder. Finally, we consider the impact of musical experience on rhythm processing and the potential value of musical rhythm in therapeutic interventions.

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“…This is consistent 470 with several previous studies reporting that individuals with ADHD generally exhibit more 471 variability in continuation-tapping vs. synchronization and are also more variable relative to 472 controls (Rubia et The overall emerging pattern from studying these three types of motor tapping 491 behaviors suggests the following: Individuals with ADHD seem to have an inherent deficit in 492 maintaining internal timing and generating isochronous rhythms based on internal motor-493 oscillations alone. This manifests both in their reduced ability to produce isochronous 494 spontaneous tapping as well as in increased variability in continuation tapping, that imposes 495 Supporting this distinction, a recent study suggest that the timing impairments in ADHD stem 500 from higher level factors such as sustained attention, rather than low-level sensorimotor timing 501 (Hove et al 2017). 502…”

Section: Motor Tapping Deficits In Adhd 445mentioning

confidence: 99%

Spontaneous and Stimulus-Driven Rhythmic Behaviors in ADHD Adults and Controls

Amrani

Golumbic

2019

Preprint

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1 2 Many aspects of human behavior are inherently rhythmic, requiring production of rhythmic 3 motor actions as well as synchronizing to rhythms in the environment. It is well-established 4 that individuals with ADHD exhibit deficits in temporal estimation and timing functions, which 5 may impact their ability to accurately produce and interact with rhythmic stimuli. In the current 6 study we seek to understand the specific aspects of rhythmic behavior that are implicated in 7 ADHD. We specifically ask whether they are attributed to imprecision in the internal 8 generation of rhythms or to reduced acuity in rhythm perception. We also test key predictions 9 of the Preferred Period Hypothesis, which suggests that both perceptual and motor rhythmic 10 behaviors are biased towards a specific personal 'default' tempo. To this end, we tested a 11 several aspects of rhythmic behavior, including spontaneous motor tapping (SMT), perceptual 12 preferences (PPT) and synchronization-continuations tapping in a broad range of rhythms, 13 from sub-second to supra-second rates. Moreover, we evaluate the intra-subject consistency of 14 rhythmic preferences, as a means for testing the reality and reliability of personal 'default-15 rhythms'. 1617 Results indicate that individuals with ADHD are primarily challenged in producing self-18 generating isochronous motor rhythms, during both spontaneous and memory-paced tapping. 19 However, they nonetheless exhibit a high degree of flexibility in synchronizing to a broad range 20 of external rhythms. These findings suggest that auditory-motor entrainment is preserved in 21 ADHD, and that the presence of an external pacer allows overcoming the inherent difficulty in 22 Some have argued that these default motor preferences also extend to the realm of auditory 64 perception. Specifically, McAuley and colleagues (2006) report a one-to-one correspondence 65 between individual SMTs and the tempo that individuals indicate is most 'comfortable' for 66 them to listen to, labeled their Preferred Perceptual Tempo (PPT). This finding prompted 67 the Preferred Period Hypothesis, suggesting that individuals have a characteristic preferred 68 rhythm, that is generalized across perception and production, and can be attributed to a 69 common internal oscillator (McAuley 2010;Michaelis et al. 2014;Provasi et al. 2014; 70 Schwartze and Kotz 2015). Moreover, according to this perspective, preferred internal rhythms 71 also influence behavior, facilitating perceptual, motor and inter-personal synchronization at 72 rhythms near one's SMT (Styns and Leman 2007;Large and Gray 2015;Zamm et al. 2015). 73 However, to date, the consistency of 'default' motor and perceptual preferences within 74 individuals and the degree to which they indeed generalize across rhythmic behaviors, has been 75 somewhat debated (van der Wel et al. 2009;McPherson et al. 2018;Qi et al. 2019). Moreover, 76 the manifestation of internal motor and perceptual rhythmic preferences in clinical populations 77 who exhibit timing-related de...

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Finger tapping and pre-attentive sensorimotor timing in adults with ADHD

Cited by 24 publications

References 50 publications

Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice

Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice

Timing Deficits in ADHD: Insights From the Neuroscience of Musical Rhythm

Spontaneous and Stimulus-Driven Rhythmic Behaviors in ADHD Adults and Controls

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