Finger taps and constipation are closely related to symptoms of overactive bladder in male patients with Parkinson's disease

Abstract

Abbreviations & AcronymsObjectives: To assess which motor and non-motor symptoms are closely related to overactive bladder severity in male patients with Parkinson's disease. Methods: A total of 160 male patients (mean age 71.4 ± 8.2 years) diagnosed with Parkinson's disease were included in the present study at Osaka University and affiliated hospitals. The severity of Parkinson's disease was classified as stage 3, 4 or 5 based on the Hoehn and Yahr staging system. Disease duration was 8.9 ± 5.1 years. Age, seven items from the Unified Parkinson's Disease Rating Scale motor section part III and three non-motor symptoms were assessed by multivariate analysis for their impact on the overactive bladder symptom score, a specific questionnaire for overactive bladder. Results: Overactive bladder symptom score was significantly higher in the group with severe motor symptoms related to finger taps and gait than in the group with mild motor symptoms related to these two factors. Furthermore, overactive bladder symptom score of patients with erectile dysfunction and constipation was significantly higher than that in patients without these symptoms. Multivariate analysis identified only finger taps and constipation as factors independently associated with overactive bladder symptom score. Conclusions: Although a study on a larger scale is required to further assess the association of Parkinson's disease symptoms with overactive bladder symptom score, information on finger taps and severity of constipation should be obtained when assessing urological patients with Parkinson's disease.

Constipation is reduced by beta-blockers and increased by dopaminergic medications in Parkinson's disease

“…Some NMS were significant predictors of constipation, including urinary urgency, nocturia, OH and attention deficits, suggesting a common underlying pathogenetic process involving the sympathetic nervous system. Constipation has been previously associated with urinary dysfunction and symptoms of detrusor hyperactivity, such as urgency and nocturia, in PD patients [26]. Abnormal noradrenergic activity may explain bladder hyperactivity [27], which is exacerbated by both levodopa and dopamine agonists [28], similar to what has been observed in our study for constipation.…”

The association between lower urinary tract symptoms and falls: Forming a theoretical model for a research agenda

“…For example, as well as being associated with arterial disease, diabetes mellitus has well documented effects on the lower urinary tract and is associated with impaired bladder emptying and urgency, and can cause neuropathies that may predispose to falls including peripheral neuropathy causing gait disturbance and autonomic neuropathy causing postural hypotension . Likewise, Parkinson's disease is commonly associated with both LUTS and falls . There are, therefore, many illnesses and conditions which cause both LUTS and falls, and future epidemiological research should ensure that these potential confounders are accurately accounted for in the analysis.…”

Lower urinary tract symptoms in Parkinson's disease: Prevalence, aetiology and management

“…Some studies have suggested that the presence and severity of LUTS are correlated with disease severity [3,8,10,11,14,26,27] However, others have failed to show an association [7,9,28]. Wing et al reported that number of LUTS accessed using the IPSS was not associated with disease severity but that the number of bothersome symptoms (assessed using Dan-PSS) did correlate with Hoehn and Yahr stage.…”