Fingerprick Versus Oral Swab: Acceptability of Blood-Based Testing Increases If Other STIs Can Be Detected

Balán, Iván C.; Frasca, Timothy; Ibitoye, Mobolaji; Dolezal, Curtis; Carballo‐Diéguez, Alex

doi:10.1007/s10461-016-1497-4

Cited by 24 publications

(22 citation statements)

References 12 publications

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“…Besides urine samples and anorectal and oropharyngeal swabs, the test kit included a blood sample to test for syphilis and HBV. Our study confirmed that most MSM considered finger prick blood sampling feasible and acceptable based on the previous studies [23,24].…”

Section: Discussionsupporting

confidence: 88%

Pilot implementation of a home-care programme with chlamydia, gonorrhoea, hepatitis B, and syphilis self-sampling in HIV-positive men who have sex with men

et al. 2020

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Background Not all men who have sex with men (MSM) at risk for sexually transmitted infections (STIs) and human immunodeficiency virus (HIV) infection currently receive sexual healthcare. To increase the coverage of high-quality HIV/STI care for MSM, we developed a home-care programme, as extended STI clinic care. This programme included home sampling for testing, combined with treatment and sexual health counselling. Here, we pilot implemented the programme in a hospital setting (HIV-positive MSM) to determine the factors for the successful implementation of STI home sampling strategies. Methods Healthcare providers from the HIV hospital treatment centre (Maastricht) were invited to offer free STI sampling kits (syphilis, hepatitis B, [extra]genital chlamydia and gonorrhoea laboratory testing) to their HIV-positive MSM patients (March to May 2018). To evaluate implementation of the program, quantitative and qualitative data were collected to assess adoption (HIV care providers offered sampling kits to MSM), participation (MSM accepted the sampling kits) and sampling-kit return, STI diagnoses, and implementation experiences. Results Adoption was 85.3% (110/129), participation was 58.2% (64/110), and sampling-kit return was 43.8% (28/64). Of the tested MSM, 64.3% (18/28) did not recently (< 3 months) undergo a STI test; during the programme, 17.9% (5/28) were diagnosed with an STI. Of tested MSM, 64.3% (18/28) was vaccinated against hepatitis B. MSM reported that the sampling kits were easily and conveniently used. Care providers (hospital and STI clinic) considered the programme acceptable and feasible, with some logistical challenges. All (100%) self-taken chlamydia and gonorrhoea samples were adequate for testing, and 82.1% (23/28) of MSM provided sufficient self-taken blood samples for syphilis screening. However, full syphilis diagnostic work-up required for MSM with a history of syphilis (18/28) was not possible in 44.4% (8/18) of MSM because of insufficient blood sampled. Conclusion The home sampling programme increased STI test uptake and was acceptable and feasible for MSM and their care providers. Return of sampling kits should be further improved. The home-care programme is a promising extension of regular STI care to deliver comprehensive STI care to the home setting for MSM. Yet, in an HIV-positive population, syphilis diagnosis may be challenging when using self-taken blood samples.

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Section: Discussionsupporting

confidence: 88%

Pilot implementation of a home-care programme with chlamydia, gonorrhoea, hepatitis B, and syphilis self-sampling in HIV-positive men who have sex with men

et al. 2020

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“…A variety of statistical approaches were used in these studies, most commonly logistic regression (13, 39%) [ 73 – 85 ] and Chi squared tests (including Pearson’s and Fisher’s exact) (12, 36%) [ 24 , 25 , 73 , 75 , 80 , 83 , 86 – 91 ]. T-tests (5, 15%) and analysis of variance (4, 12%) [ 24 , 86 , 88 , 91 ] were also employed, as well as types of regression (linear [ 92 , 93 ], count [ 94 ], log binomial [ 95 ], ordinary least squares [ 96 ], and logit link [ 97 ]). Three studies used Mann–Whitney U tests (9%) [ 81 , 93 , 98 ].…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies investigated combinations of voluntary testing and counseling product and service design [ 24 , 28 , 44 , 45 , 50 , 53 – 55 , 86 , 88 , 93 , 95 , 96 , 99 , 102 ].…”

Section: Resultsmentioning

confidence: 99%

“…Most of the DCE studies (24/28, 86%) further measured preference heterogeneity using stratification/subgroup analyses and/or interaction terms (17, 61%), or latent class analysis (6, 21%) [29,33,40,46,51,52]. One study used a blocked design with two different versions of the DCE for the two a priori sub-groups (past HIV testers vs non-testers) [ 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 [24,86,88,91] were also employed, as well as types of regression (linear [92,93], count [94], log binomial [95], ordinary least squares [96], and logit link [97]). Three studies used Mann-Whitney U tests (9%) [81,93,98].…”

Section: Dcementioning

confidence: 99%

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Eliciting Preferences for HIV Prevention Technologies: A Systematic Review

Beckham

Crossnohere

Gross

et al. 2020

Patient

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Background Many human immunodeficiency virus (HIV) prevention technologies (pre-exposure prophylaxis, microbicides, vaccines) are available or in development. Preference elicitation methods provide insight into client preferences that may be used to optimize products and services. Given increased utilization of such methods in HIV prevention, this article identifies and reviews these methods and synthesizes their application to HIV prevention technologies. Methods In May 2020, we systematically searched peer-reviewed literature in PubMed, CINAHL, and Web of Science for studies employing quantitative preference elicitation methods to measure preferences for HIV prevention technologies among populations of any age, sex, or location. Quality assessment used an existing checklist (PREFS) and a novel adaptation of the Newcastle–Ottawa Scale (PROSPERO #CRD42018087027). Results We screened 5022 titles and abstracts, reviewed 318 full texts, and included 84 studies. Common methods employed were discrete-choice experiment (33%), conjoint analysis (25%), and willingness-to-participate/try/accept (21%). Studies were conducted in 25 countries and had a mean of 768 participants (range = 26–7176), two-thirds of them male. Common HIV prevention technologies included pre-exposure prophylaxis (23%), voluntary testing and counseling (19%), HIV self-testing (17%), vaccines (15%), and topical microbicides (9%). Most attributes focused on product design (side effects, frequency), service design (provider type, location), acceptability or willingness to accept/pay; results are summarized in these categories, by prevention type. Mean quality-adapted Newcastle–Ottawa Scale score was 4.5/8 (standard deviation = 2.1) and mean PREFS scores was 3.47/5 (standard deviation = 0.81). Conclusions This review synthesizes extant literature on quantitative measurement of preferences for HIV prevention technologies. This can enable practitioners to improve prevention products and interventions, and ultimately reduce HIV incidence.

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“…In a study in Vietnam MSM and female sex workers (FSW) preferred oral fluid HIVSTs, while injection drug users (IDU) preferred blood based kits (25). In work from the US conducted with an ethnically diverse group of high risk MSM, more frequent testers preferred blood based testing, whereas men who tested less frequently preferred oral fluid HIVSTs (35).…”

Section: Understanding Implementation Contexts: Values and Preferencesmentioning

confidence: 99%

New initiatives to develop self-testing for HIV

Witzel

Rodger

2017

Current Opinion in Infectious Diseases

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Purpose of the review: The purpose is to describe the most recent literature associated with HIV self -testing (HIVST). Recent findings:HIVST is acceptable to a range of populations in a variety of contexts, particularly if users values and preferences are taken into account in intervention development. Approaches being explored in on-going and planned studies are the efficacy of HIVST to increase diagnosis of longstanding prevalent infections and to reduce the interval between HIV transmission and diagnosis, particularly in high incidence groups. Though there is little evidence of harms related to HIVST, this remains a potential issue. Concerns remain about the reliability of currently available HIVST kits, which have lower sensitivity than testing options available in clinical settings, particularly in early HIV infection. Evidence on linkage to care for confirmatory testing after a reactive HIVST result and the cost effectiveness of HIVST to increase rates of HIV diagnosis is currently limited. Summary:HIVST is relatively new innovation that appears acceptible to key populations and which could increase HIV testing rates and rates of HIV diagnosis especially in at-risk groups. Concerns

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Fingerprick Versus Oral Swab: Acceptability of Blood-Based Testing Increases If Other STIs Can Be Detected

Cited by 24 publications

References 12 publications

Pilot implementation of a home-care programme with chlamydia, gonorrhoea, hepatitis B, and syphilis self-sampling in HIV-positive men who have sex with men

Pilot implementation of a home-care programme with chlamydia, gonorrhoea, hepatitis B, and syphilis self-sampling in HIV-positive men who have sex with men

Eliciting Preferences for HIV Prevention Technologies: A Systematic Review

New initiatives to develop self-testing for HIV

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