Based on continuum damage mechanics, progressive damage analysis of composite bolted joints with ply ratios of [(0o)30%/(±45o)60%/(90o)10%] and [(0o)70%/(±45o)20%/(90o)10%] is investigated in this paper. First of all, a new strength criterion is proposed to evaluate the intralaminar (fiber and matrix) and interlaminar damage initiation of composite materials. Then, an exponential material degradation model is adopted to describe the progressive damage process of composite materials. Finally, a continuum damage mechanics model is developed to predict the progressive damage behavior of composite bolted joints with different ply ratios. The predticted results have a good agreement with the experimental values. It is shown that low ±45o ply ratio induces the shear-out failure mode of composite bolted joints, decreasing the load carrying capacity.