The two‐dimensional mixed convective MHD flow with heat and mass transfer is investigated for its behavior with Dufour and Soret mechanisms over the porous sheet. The copper–alumina (Cu–Al2O3) hybrid nanoparticles are used in the base fluid water. The governing system of partial differential equations is converted into a system of ordinary differential equations via similarity transformations, obtaining the solution for velocity, temperature, and concentration fields in exponential form. The problem is demonstrated in the Darcy–Brinkman model, the impact of included parameters such as Richardson number, magnetic field, and Dufour numbers are studied for the obtained solution with the help of graphs. Increasing the magnetic field decreases both transverse and axial velocity profiles. Increasing the magnetic field and Richardson's number decreases the solution (Al2O3–H2O). Increasing the values magnetic field and Richardson's number decreases both transverse and axial velocity profiles. Increasing the values of the Dufour effect increases the axial and transverse velocity boundary layer. The magnetohydrodynamic hybrid nanofluid flow over porous media works efficiently in liquid cooling and, therefore, has significant applications in industrial heating and cooling systems, solar energy, magnetohydrodynamic flow meters and pumps, manufacturing, regenerative heat exchange, thermal energy storage, solar power collectors, geothermal recovery, and chemical catalytic reactors.