Aircraft manufacturers are investigating thermoplastic material systems to produce parts more quickly and efficiently. Detailed damage data is needed to evaluate existing damage analysis methods, developed for thermoset materials, to predict damage in thermoplastic materials. Damage maps were created for two thermoplastic material systems subjected to low-velocity impact over a range of impact energies. In this paper, the damage maps were used to investigate and compare the damage response of the different material systems. Impact specimens were manufactured from TC1225 LMPAEK T700G from Toray Industries and APC AS4D/PEKK-FC from Solvay. The effect of the degree of crystallinity on the damage response was also investigated using a third set of specimens manufactured using the Toray material and a quenching process. Using a combination of data obtained from X-ray computed tomography and ultrasonic testing, damage maps were created for every interface and ply for selected specimens showing matrix cracks, delamination outlines, and fractured fibers. The LMPAEK specimens were found to have fewer and smaller delaminations than the PEKK specimens for impacts at the same energy. However, the LMPAEK specimens contained a larger number of fiber breaks. A similar trend was observed when comparing low-crystallinity LMPAEK specimens with the baseline LMPAEK specimens. The LMPAEK specimens often contained lines of fiber fractures in near-surface plies emanating from the contact region that were not present in the PEKK specimens. The different damage responses may indicate that the material selection will be a function of the application and loading.