Finite-element design and optimization of a three-dimensional tetrahedral porous titanium scaffold for the reconstruction of mandibular defects

Luo, Danmei; Rong, Qin; Chen, Quan

doi:10.1016/j.medengphy.2017.06.015

Cited by 62 publications

(28 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ti has been attractive for clinical use because of its excellent load-bearing properties, biocompatibility, and high corrosion resistance [ 32 ]. Today, with the help of digital medicine and computer-aided technology, a 3D-printed porous Ti scaffold could mimic bone tissue morphology and mechanical behavior functionally and aesthetically, thus helping to reconstruct mandibular bone defects [ 33 , 34 ]. The 3D-printed implants can reconstruct complex defective sections anatomically using a mirror image of the unaffected side [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Today, with the help of digital medicine and computer-aided technology, a 3D-printed porous Ti scaffold could mimic bone tissue morphology and mechanical behavior functionally and aesthetically, thus helping to reconstruct mandibular bone defects [ 33 , 34 ]. The 3D-printed implants can reconstruct complex defective sections anatomically using a mirror image of the unaffected side [ 34 , 35 ]. In this study, 3D-printed Ti6Al4V scaffolds with more than 80% porosity can accommodate new bone and provide an adequate biological fixation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

3D Culture of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) Could Improve Bone Regeneration in 3D-Printed Porous Ti6Al4V Scaffolds

Liu

et al. 2018

Stem Cells International

View full text Add to dashboard Cite

Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstruction, which makes them potential candidates for mandibular bone defect reconstruction implants. However, in clinical practice, the insufficient osteogenesis of the scaffolds needs to be further improved. In this study, we first encapsulated bone marrow-derived mesenchymal stem cells (BMSCs) into Matrigel. Subsequently, the BMSC-containing Matrigels were infiltrated into porous Ti6Al4V scaffolds. The Matrigels in the scaffolds provided a 3D culture environment for the BMSCs, which was important for osteoblast differentiation and new bone formation. Our results showed that rats with a full thickness of critical mandibular defects treated with Matrigel-infiltrated Ti6Al4V scaffolds exhibited better new bone formation than rats with local BMSC injection or Matrigel-treated defects. Our data suggest that Matrigel is able to create a more favorable 3D microenvironment for BMSCs, and Matrigel containing infiltrated BMSCs may be a promising method for enhancing the bone formation properties of 3D-printed Ti6Al4V scaffolds. We suggest that this approach provides an opportunity to further improve the efficiency of stem cell therapy for the treatment of mandibular bone defects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

3D Culture of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) Could Improve Bone Regeneration in 3D-Printed Porous Ti6Al4V Scaffolds

Liu

et al. 2018

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…laser melted Ti6Al4V which is the standard practice [139][140][141][142]. However, a more effective alternative could be the use of slightly porous cylindrical cubes under compression to derive the material properties.…”

Section: Elastic-plastic Performancementioning

confidence: 99%

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

Arjunan

Demetriou

Baroutaji

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

125

View full text Add to dashboard Cite

Critically engineered stiffness and strength of a scaffold are crucial for managing maladapted stress concentration and reducing stress shielding. At the same time, suitable porosity and permeability are key to facilitate biological activities associated with bone growth and nutrient delivery. A systematic balance of all these parameters are required for the development of an effective bone scaffold. Traditionally, the approach has been to study each of these parameters in isolation without considering their interdependence to achieve specific properties at a certain porosity. The purpose of this study is to undertake a holistic investigation considering the stiffness, strength, permeability, and stress concentration of six scaffold architectures featuring a 68.46-90.98% porosity. With an initial target of a tibial host segment, the permeability was characterised using Computational Fluid Dynamics (CFD) in conjunction with Darcy's law. Following this, Ashby's criterion, experimental tests, and Finite Element Method (FEM) were employed to study the mechanical behaviour and their interdependencies under uniaxial compression. The FE model was validated and further extended to study the influence of stress concentration on both the stiffness and strength of the scaffolds. The results showed that the pore shape can influence permeability, stiffness, strength, and the stress concentration factor of Ti6Al4V bone scaffolds. Furthermore, the numerical results demonstrate the effect to which structural performance of highly porous scaffolds deviate, as a result of the Selective Laser Melting (SLM) process. In addition, the study demonstrates that stiffness and strength of bone scaffold at a targeted porosity is linked to the pore shape and the associated stress concentration allowing to exploit the design freedom associated with SLM.

show abstract

“…When the correlation between bone structure and mechanical stresses was pointed out with the use of FEA, research on the influence of mechanical load on cell differentiation and tissue development flourished, especially in the field of skeletal tissue engineering scaffolds [ 52 ]. The influence of the different structural configurations and porosity of the scaffold on the distribution of stresses and strains was an issue in several FEA studies [ 50 , 51 ]. Hu et al used CBCT images of a 50-year-old edentulous patient to reconstruct a 3D mandible and create an FEA model in which a segment of the mandibular body was virtually erased.…”

Section: Reconstructive Surgerymentioning

confidence: 99%

Application of Finite Element Analysis in Oral and Maxillofacial Surgery—A Literature Review

Lisiak-Myszke¹,

Marciniak

Bieliński

et al. 2020

Materials

View full text Add to dashboard Cite

In recent years in the field of biomechanics, the intensive development of various experimental methods has been observed. The implementation of virtual studies that for a long time have been successfully used in technical sciences also represents a new trend in dental engineering. Among these methods, finite element analysis (FEA) deserves special attention. FEA is a method used to analyze stresses and strains in complex mechanical systems. It enables the mathematical conversion and analysis of mechanical properties of a geometric object. Since the mechanical properties of the human skeleton cannot be examined in vivo, a discipline in which FEA has found particular application is oral and maxillofacial surgery. In this review we summarize the application of FEA in particular oral and maxillofacial fields such as traumatology, orthognathic surgery, reconstructive surgery and implantology presented in the current literature. Based on the available literature, we discuss the methodology and results of research where FEA has been used to understand the pathomechanism of fractures, identify optimal osteosynthesis methods, plan reconstructive operations and design intraosseous implants or osteosynthesis elements. As well as indicating the benefits of FEA in mechanical parameter analysis, we also point out the assumptions and simplifications that are commonly used. The understanding of FEA’s opportunities and advantages as well as its limitations and main flaws is crucial to fully exploit its potential.

show abstract

Finite-element design and optimization of a three-dimensional tetrahedral porous titanium scaffold for the reconstruction of mandibular defects

Cited by 62 publications

References 34 publications

3D Culture of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) Could Improve Bone Regeneration in 3D-Printed Porous Ti6Al4V Scaffolds

3D Culture of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) Could Improve Bone Regeneration in 3D-Printed Porous Ti6Al4V Scaffolds

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

Application of Finite Element Analysis in Oral and Maxillofacial Surgery—A Literature Review

Contact Info

Product

Resources

About