Finite-Element Modeling and Analysis in Nanomedicine and Dentistry

Choi, Andy H.; Conway, Richard C.; Ben‐Nissan, Besim

doi:10.2217/nnm.14.75

Cited by 34 publications

(30 citation statements)

References 73 publications

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“…Most of the new engineering concepts pass by this phase as it is a good tool to optimize the designs, to increase the accuracy and to reduce the number of physical prototypes. In dentistry, it is often applied and validated by comparing FEAresults with in vitro results [12,13]. For this study, it was crucial to limit the variables between the groups to the restorative technique only, to confirm whether the technique is beneficial or not.…”

Section: Discussionmentioning

confidence: 99%

Novel non-invasive reinforcement of MOD cavities on endodontically treated teeth

Daher

Feilzer

Krejci

2016

Journal of Dentistry

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A B S T R A C TObjectives: To evaluate the biomechanical influence of reconnecting the buccal and lingual walls of endodontically treated lower molar with a large MOD cavity. Methods: 3D models were created from a micro-CT scan of an extracted intact lower human molar. Finite element analysis was then used to compare the stress distribution and displacement of the structures between different models: Unrestored MOD on ETT (Unrest), MOD on ETT restored with composite resin (Norm), MOD on ETT reinforced with a non-invasive ring (Ring) and intact tooth as the control (Int).Results: This study showed that the Unrest model presented the highest stress values at the cervical level. The non-invasive Ring model showed the lowest stress values at the cervical level, and the lowest deflection of the cusps. Conclusions: Mechanically reconnecting the remaining tooth structures has a direct positive effect on stress distribution and deformation of the remaining structures. Clinical relevance: Reinforcing ETT in a non-invasive direct approach is efficient in terms of preserving sound tooth structures, reducing the time of treatment and eliminating the laboratory steps required to create the restorations.

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Section: Discussionmentioning

confidence: 99%

Novel non-invasive reinforcement of MOD cavities on endodontically treated teeth

Daher

Feilzer

Krejci

2016

Journal of Dentistry

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“…Hence it was believed that the activity of ZnO nanoparticles was presumably related to the free zinc ions released into the cells. [36] Most of the studies performed on ZnO nanoparticles invitro suggest that cellular apoptosis enhancement and ROS generation played a major role in the anticancer effect. [33,37] Conclusion A green mediated synthesis of ZnO Nps was reported for the first time using HCA isolated from the rinds of Garcinia gummi gutta.…”

Section: In-vitro Cytotoxicitymentioning

confidence: 99%

Biological Activity of ZnO Nanoparticles Synthesized from the Dried Rinds of Garcinia Gummi Gutta

Mannarmannan

Biswas

2019

ChemistrySelect

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In the current study, we have reported a novel approach for synthesizing zinc oxide Nanoparticles (ZnO Nps) from (−)‐Hydroxy Citric Acid [(−)‐HCA] extracted from the dried rinds of the fruit Garcinia gummi‐gutta. The prepared nanoparticles were characterized by UV‐Vis spectroscopy (UV‐Vis), Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive X‐ray analysis (EDAX) and High‐resolution transmission electron microscopy (HR‐TEM). Hydroxy citric acid (HCA) was used as a template to synthesize the ZnO Nps. The presence of (−)‐HCA was confirmed by High‐performance liquid chromatography (HPLC). Spherical clusters built of nanoparticle aggregates with the desired composition of ZnO were confirmed from the SEM‐EDAX and HRTEM analysis. The synthesized ZnO Nps showed a positive response for antibacterial, antifungal, antioxidant and cytotoxicity activities.

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“…The nano-indentation (NI) method has recently been introduced and employed in many animal studies as an effective method for measuring the mechanical properties of a narrow region in living tissues and biomaterials [18]. With this method, Young's modulus and hardness are routinely obtained by continuously monitoring the load and displacement during the indentation process, and constructing a load-displacement curve [19].…”

Section: Introductionmentioning

confidence: 99%

Potential for estimation of Young's modulus based on computed tomography numbers in bone: A validation study using a nano-indentation test on murine maxilla

Inagawa¹,

Suzuki²,

Aoki³

et al. 2018

Dent Oral Craniofac Res

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The accuracy of Young's modulus of bone estimated from computed tomography (CT) values has not been evaluated by means of nano-indentation (NI) measurements. This study tested the validity of an equation for obtaining Young's modulus from CT-derived bone mineral density (BMD). Maxillary bones of 17-week-old male C57BL/6J mice (n=9) were scanned by micro-CT (µCT) after sacrifice, and subsequently subjected to NI (n=5) in wet conditions at two regions of interest (ROI). These ROIs were placed in the cortical bone of the hard palate on a section parallel to the frontal plane near the incisor teeth; one at the top of the palate close to the median (ROI-1), and the other approximately 500 µm outside of ROI-1 (ROI-2). The modulus of each indent was calculated using the method of Oliver and Pharr, while BMD was estimated from the CT number of each corresponding voxel. The average Young's modulus for ROI-1 (19.38±3.49 GPa) was statistically significantly lower than that for ROI-2 (28.91±5.06 GPa) (p<0.05), while BMD did not differ significantly between ROI-1 (1.27±0.13 g/cm 3 ) and ROI-2 (1.38±0.13 g/cm 3 ). The Young's modulus (E)-BMD (ρ) relationship was obtained as a power regression model for ROI-1 (E=16.748ρ 0.662 , R 2= 0.256, p=0.163) and ROI-2 (E=17.486ρ1.596 , R 2= 0.661, p=0.013). The relatively weak correlation for ROI-1 was presumably in association with the limitation of current µCT resolution, which could not capture non-homogeneous microstructures. The results suggest that the potential for estimating Young's modulus in local bone structures is limited when based solely on the CT numbers.

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Finite-Element Modeling and Analysis in Nanomedicine and Dentistry

Cited by 34 publications

References 73 publications

Novel non-invasive reinforcement of MOD cavities on endodontically treated teeth

Novel non-invasive reinforcement of MOD cavities on endodontically treated teeth

Biological Activity of ZnO Nanoparticles Synthesized from the Dried Rinds of Garcinia Gummi Gutta

Potential for estimation of Young's modulus based on computed tomography numbers in bone: A validation study using a nano-indentation test on murine maxilla

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