Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas

Castle, Nick; Liang, Junfeng; Smith, Matthew J.; Petersen, Brett; Matson, Cayman; Eldridge, Tara; Zhang, Ke; Lee, Chung‐Hao; Liu, Yingtao; Dai, Chenkai

doi:10.1101/2023.02.15.528713

2023

DOI: 10.1101/2023.02.15.528713

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Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas

Nick Castle

Junfeng Liang

Matthew J. Smith

et al.

Abstract: Cochlear implant (CI) surgery is one of the most utilized treatments for severe hearing loss. However, the effects of a successful scala tympani insertion on the mechanics of hearing are not yet fully understood. This paper presents a finite element (FE) model of the chinchilla inner ear for studying the interrelationship between the mechanical function and the insertion angle of a CI electrode. This FE model includes a three-chambered cochlea and full vestibular system, accomplished using μ-MRI and μ-CT scann… Show more

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Cited by 3 publications

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Effect of Dielectric Properties of Cochlea on Electrode Insertion Guidance Based on Impedance Variation

Salkim

2024

Applied Sciences

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The cochlear neuromodulator provides substantial auditory perception to those with impaired hearing. The accurate insertion of electrodes into the cochlea is an important factor, as misplaced may lead to further damage. The impedance measurement may be used as a marker of the electrode insertion guidance. It is feasible to investigate the impact of the dielectric properties of the cochlea tissue layers on the electrode insertion guidance using sophisticated bio-computational methods that are impractical or impossible to perform in cochlear implant (CI) patients. Although previous modeling approaches of the cochlea argued that the capacitive impact of the tissue layer can be neglected using the quasi-static (QS) approximation method, it is widely accepted that tissue acts as a frequency filter. Thus, the QS method may not always be appropriate due to short-duration pulses. This study aimed to investigate the impact of the frequency-dependent dielectric properties of the cochlea tissue layers on the impedance variation by following a systematic approach. The volume conductor model of the cochlea layers was developed, the dielectric properties of each tissue layer were attained, and the cochlea neuromodulator settings were applied to obtain the results based on both QS and transient solution (TS) methods. The results based on the QS and TS methods were compared to define to what extent these parameters affect the outcome. It was suggested that the capacitive impact of the cochlea layers should be considered after a certain frequency level.

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Effect of Dielectric Properties of Cochlea on Electrode Insertion Guidance Based on Impedance Variation

Salkim

2024

Applied Sciences

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A Virtual Inner Ear Model Selects Ramped Pulse Shapes for Vestibular Afferent Stimulation

Chen,

Sprigg,

Castle

et al. 2023

Bioengineering

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Bilateral vestibular deficiency (BVD) results in chronic dizziness, blurry vision when moving the head, and postural instability. Vestibular prostheses (VPs) show promise as a treatment, but the VP-restored vestibulo-ocular reflex (VOR) gain in human trials falls short of expectations. We hypothesize that the slope of the rising ramp in stimulation pulses plays an important role in the recruitment of vestibular afferent units. To test this hypothesis, we utilized customized programming to generate ramped pulses with different slopes, testing their efficacy in inducing electrically evoked compound action potentials (eCAPs) and current spread via bench tests and simulations in a virtual inner model created in this study. The results confirmed that the slope of the ramping pulses influenced the recruitment of vestibular afferent units. Subsequently, an optimized stimulation pulse train was identified using model simulations, exhibiting improved modulation of vestibular afferent activity. This optimized slope not only reduced the excitation spread within the semicircular canals (SCCs) but also expanded the neural dynamic range. While the model simulations exhibited promising results, in vitro and in vivo experiments are warranted to validate the findings of this study in future investigations.

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Developing a Virtual Model of the Rhesus Macaque Inner Ear

Matson,

Castle,

Dai

2024

Bioengineering

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A virtual model of the rhesus macaque inner ear was created in the present study. Rhesus macaques have been valuable in cochlear research; however, their high cost prompts a need for alternative methods. Finite Element (FE) analysis offers a promising solution by enabling detailed simulations of the inner ear. This study employs FE analysis to create a virtual model of the rhesus macaque’s inner ear, reconstructed from MRI scans, to explore how cochlear implants (CIs) impact residual hearing loss. Harmonic-acoustic simulations of sound wave transmission indicate that CIs have minor effects on the displacement of the basilar membrane and thus minimally impact residual hearing loss post-implantation, but stiffening of the round window membrane worsens this effect. While the rhesus macaque FE model presented in this study shows some promise, its potential applications will require further validation through additional simulations and experimental studies.

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Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas

Cited by 3 publications

References 47 publications

Effect of Dielectric Properties of Cochlea on Electrode Insertion Guidance Based on Impedance Variation

Effect of Dielectric Properties of Cochlea on Electrode Insertion Guidance Based on Impedance Variation

A Virtual Inner Ear Model Selects Ramped Pulse Shapes for Vestibular Afferent Stimulation

Developing a Virtual Model of the Rhesus Macaque Inner Ear

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