The vascular stents are important medical devices introduced into a vessel to protect the lumen from unfriendly stenosis. However, Nitinol stent is easy to fail in practice. The present paper focuses on the influence of defects on its mechanical behavior by finite element analysis. The essential stent cell is used with two different type of defects, which includes the face bulge defect resulted from laser burrs or TiC inclusion arises and C-contained particle voids. Auricchio's super-elastic consititutive equations are used in the finite element simulations. It is found that the stress distribution is not only related to the defect type but also to the defect position. With the increasing distance from the TiC defect to the knot's notch, the influence of defects on stress distribution of stents becomes small. For void defects, those near both the inner fillet and the outer fillet have grand influence on the stent's global stress distribution. In particular, the higher stress concentrations are undergone near knot's defects. For all models, the maximum Martensite Volume Fraction is near knots. The finite element analysis shows that cracks/fractures can easily appear near knots. A stent with a TiC inclusion or void defect is likely to fail. All obtained conclusions can be useful to design against stent premature mechanical failure.