Finite elements analysis of the temporomandibular joint disc in patients with intra-articular disorders

Lai, Linfeng; Huang, Chenyao; Zhou, Fan; Xia, Fujian; Xiong, Guofeng

doi:10.1186/s12903-020-01074-x

Cited by 24 publications

(12 citation statements)

References 32 publications

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“…Pressure on the anterior surface of condyles after disc displacement reached 931.72 ± 56.50 kPa, which was approximately 5 times higher than that before disc displacement (184.68 ± 54.60 kPa). The pressure measured directly on the anterior surface of condyles when discs were displaced without reduction corroborated a previous study using finite-element analysis ( 33 ) and indicated that increased mechanical loading on the anterior surface of condyles could be caused by disc displacement.…”

Section: Discussionsupporting

confidence: 87%

Increased joint loading induces subchondral bone loss of the temporomandibular joint via the RANTES-CCRs-Akt2 axis

Feng¹,

Lei²,

Li³

et al. 2022

JCI Insight

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Early-stage temporomandibular joint osteoarthritis (TMJOA) is characterized by excessive subchondral bone loss. Emerging evidence suggests that TMJ disc displacement is involved, but the pathogenic mechanism remains unclear.Here, we established a rat model of TMJOA that simulated disc displacement and a capacitance-based force sensing system to directly measure articular surface pressure in vivo. Micro-CT, histological staining, immunofluorescence staining, immunohistochemistry staining, and Western blot were used to assess pathological changes and underlying mechanism of TMJOA in the rat model in vivo as well as in RAW264.7 cells in vitro. We found that disc displacement led to significantly higher pressure on articular surface, which caused subchondral bone loss rapidly via activation of RANTES-CCRs-Akt2 axis. Inhibition of RANTES or Akt2 attenuated subchondral bone loss and resulted in improved subchondral bone microstructure. Cytological studies substantiated that RANTES regulated osteoclast formation by binding to its receptor CCRs and activating Akt2 pathway. The clinical evidence further supported that RANTES was a potential biomarker for predicting subchondral bone loss in early-stage TMJOA. Taken together, this study demonstrates important functions of RANTES-CCRs-Akt2 axis in the regulation of subchondral bone remodeling and provides further knowledge of how disc displacement causes TMJOA.

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Section: Discussionsupporting

confidence: 87%

Increased joint loading induces subchondral bone loss of the temporomandibular joint via the RANTES-CCRs-Akt2 axis

Feng¹,

Lei²,

Li³

et al. 2022

JCI Insight

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“…Anatomically and functionally, the intervertebral disc of the TMJ acts as a buffer between the bones of the joints during loading, protecting the underlying tissues. 31,32 However, under pathological conditions, functional forces that exceed the disc's adaptive capacity can lead to degenerative changes to the articular surfaces. 4 According to studies that included long-term radiological follow-up, degenerative changes of the articular surfaces increased with time in patients with untreated ADDNR.…”

Section: Ta B L E 1 Distribution Of Djd According To Age and Gender I...mentioning

confidence: 99%

Risk estimation of degenerative joint disease in temporomandibular disorder patients with different types of sagittal and coronal disc displacements: MRI and CBCT analysis

Fan

Xiong

Cheng

et al. 2022

J of Oral Rehabilitation

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Background Degenerative joint disease (DJD) can be associated with disc displacement (DD) in temporomandibular disorder (TMD) patients. However, the relationship between different types of DDs and DJD remains unclear. Objectives To investigate the odds ratios of different types of sagittal and coronal DDs confirmed by magnetic resonance imaging (MRI) and DJD confirmed by cone‐beam computed tomography (CBCT) in TMD patients. Methods Radiographic data from 69 males and 232 females were collected for analysis. CBCT was used to diagnose DJD, with criteria including erosion, osteophytes, generalised sclerosis and cysts in the joint. Eight types of DDs were evaluated by sagittal and coronal MRIs: NA, no abnormality; SW, sideways; ADDR, anterior with reduction; ADDR+SW; ADDNR, anterior without reduction; ADDNR + SW; single SW; PDD, posterior; PDD + SW. The odds ratios of DJD in joints with different types of DDs were determined after joint correlation, age and gender adjustment. Results Compared with NA, the odds ratio of DJD in ADDR was 2.397 (95% CI [confidence interval]: 1.070–5.368), ADDR + SW was 4.808 (95% CI: 1.709–3.528), ADDNR was 29.982 (95% CI: 15.512–57.950) and ADDNR + SW was 25.974 (95% CI: 12.743–52.945). Erosion was significantly increased in ADDR, ADDR + SW, ADDNR and ADDNR + SW; osteophytes were significantly increased in ADDR + SW, ADDNR and ADDNR + SW; and generalised sclerosis and cysts were significantly increased in ADDNR and ADDNR + SW. There were no significant associations between single SW, PDD, PDD + SW and the DJD. Conclusions ADDR, ADDR+SW, ADDNR and ADDNR+SW were associated with DJD. ADDNR had a significantly higher prevalence of DJD than ADDR. There were no significant relationships between single SW, PDD, PDD + SW and the DJD.

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“…Finite element analysis (FEA) was usually used in the study of oral biomechanics (Dicker et al, 2012;Qi et al, 2012;Liu et al, 2016;Demircan et al, 2020;Lai et al, 2020). Several interactions were considered in the simulation of TMJ (Liu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

3D Printing Experimental Validation of the Finite Element Analysis of the Maxillofacial Model

Shu

Luo

Zhang³

et al. 2021

Front. Bioeng. Biotechnol.

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Contacts used in finite element (FE) models were considered as the best simulation for interactions in the temporomandibular joint (TMJ). However, the precision of simulations should be validated through experiments. Three-dimensional (3D) printing models with the high geometric and loading similarities of the individuals were used in the validation. This study aimed to validate the FE models of the TMJ using 3D printing models. Five asymptomatic subjects were recruited in this study. 3D models of mandible, disc, and maxilla were reconstructed according to cone-beam CT (CBCT) image data. PLA was chosen for 3D printing models from bottom to top. Five pressure forces corresponding to the central occlusion were applied to the 3D printing models. Ten strain rosettes were distributed on the mandible to record the horizontal and vertical strains. Contact was used in the FE models with the same geometries, material properties, loadings, and boundary conditions as 3D printing models to simulate the interaction of the disc-condyle, disc-temporal bone, and upper-lower dentition. The differences of the simulated and experimental results for each sample were less than 5% (maximum 4.92%) under all five loadings. In conclusion, it was accurate to use contact to simulate the interactions in TMJs and upper-lower dentition.

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Finite elements analysis of the temporomandibular joint disc in patients with intra-articular disorders

Cited by 24 publications

References 32 publications

Increased joint loading induces subchondral bone loss of the temporomandibular joint via the RANTES-CCRs-Akt2 axis

Increased joint loading induces subchondral bone loss of the temporomandibular joint via the RANTES-CCRs-Akt2 axis

Risk estimation of degenerative joint disease in temporomandibular disorder patients with different types of sagittal and coronal disc displacements: MRI and CBCT analysis

3D Printing Experimental Validation of the Finite Element Analysis of the Maxillofacial Model

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