Abstract-Novel low-density signature (LDS) structure is proposed for transmission and detection of symbol-synchronous communication over memoryless Gaussian channel. Given as the processing gain, under this new arrangement, users' symbols are spread over chips but virtually only chips that contain nonzero-values. The spread symbol is then so uniquely interleaved as the sampled, at chip rate, received signal contains the contribution from only number of users, where denotes the total number of users in the system. Furthermore, a near-optimum chip-level iterative soft-in-soft-out (SISO) multiuser decoding (MUD), which is based on message passing algorithm (MPA) technique, is proposed to approximate optimum detection by efficiently exploiting the LDS structure. Given = as the system loading, our simulation suggested that the proposed system alongside the proposed detection technique, in AWGN channel, can achieve an overall performance that is close to single-user performance, even when the system has 200% loading, i.e., when = 2. Its robustness against near-far effect and its performance behavior that is very similar to optimum detection are demonstrated in this paper. In addition, the complexity required for detection is now exponential to instead of as in conventional code division multiple access (CDMA) structure employing optimum multiuser detector. Index Terms-Chip-level iterative SISO MUD, Gaussian channel, low-density signature, message passing algorithm, overloaded condition.