Wall pressure fluctuations and flow noise substantially degrade sonar detection performance and the acoustic stealth performance of underwater vehicles. This paper numerically investigates the effects of wall heating on wall pressure fluctuations in turbulent channel flow of water with temperature-dependent viscosity, exploring a novel method for controlling wall pressure fluctuations and flow noise in underwater vehicles. Large-eddy simulation (LES) is employed for the numerical calculation of the flow field, while a hybrid method combining LES with Lighthill’s acoustic analogy is employed to predict flow noise. The numerical results show that when the temperature difference between the wall and the incoming flow is 30 K and 50 K, the peak root-mean-square pressure fluctuations decrease by 6.76% and 8.91%, respectively. Wall heating stabilizes the pressure field near the wall, with the spectral levels of wall pressure fluctuations showing average decreases of approximately 1 dB and 2 dB. Wall heating weakens the energy-containing structures of wall pressure fluctuations and increases the overall convection velocity by 1.22% and 3.81%, respectively. Flow structure analysis reveals that the weakening of energy-containing structures results from the suppression of the vortex structures in the near-wall region. In the wall heating cases, peak turbulent kinetic energy decreases by 12.6% and 15.8%, respectively. Moreover, the sound pressure level of flow noise decreases with increasing wall temperature, with the maximum noise reduction exceeding 3 dB. Previous studies have not yet explored the effects of viscosity reduction caused by wall heating on wall pressure fluctuations and flow noise. This study demonstrates that wall heating is a promising method for reducing wall pressure fluctuations and flow noise.