Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies

Pan, Yunfeng; Song, Xueru; Wang, Yue; Wei, Jia

doi:10.3390/pharmaceutics13091338

Cited by 2 publications

(2 citation statements)

References 113 publications

(120 reference statements)

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“…The excellent performance of biological nanomaterials owing to their structural diversity, their roles as highly efficient drug delivery systems, targeted binding, and high treatment success rate still make them an important breakthrough in treating related conditions. [38] Examples include cancer treatment, [39,40] improvement of cardiovascular diseases, [41,42] and the repair and regeneration of cartilage and joints. [43,44] The widespread utilization of this treatment method, both in animal experiments and clinical trials, has achieved remarkable curative effects.…”

Section: Synthesis and Characterization Of Nanoparticlesmentioning

confidence: 99%

Nucleus Pulposus‐Targeting Nanocarriers Facilitate Mirna‐Based Therapeutics for Intervertebral Disc Degeneration

Chen,

Liao,

Liu

et al. 2023

Adv Healthcare Materials

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Intervertebral disc degeneration (IDD) is a common cause of low back pain. Understanding its molecular mechanisms is the basis for developing specific treatment. To demonstrate that miR‐22‐3p is critical in the regulation of IDD, we conducted miRNA microarray analyses in conjunction with in vivo and in vitro experiments. The miR‐22‐3p knockout (KO) mice showed a marked decrease in the histological scores. Bioinformatic analysis revealed that miR‐22‐3p plays a mechanistic role in the development of IDD by targeting SIRT1, which in turn activates the JAK1/STAT3 signaling pathway. This was confirmed by a luciferase reporter assay and western blot analysis. Therapeutically, the delivery of miR‐22‐3p inhibitors and mimics through our synthesized nanoparticles in the IDD model alleviated and aggravated IDD, respectively. The nanocarriers enhanced transportation of miR‐22‐3p to nucleus pulposus (NP) cells, thus enabling the in vivo inhibition of miR‐22‐3p for therapeutic purposes and consequently promoting the development of miRNA‐specific drugs for IDD.This article is protected by copyright. All rights reserved

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Section: Synthesis and Characterization Of Nanoparticlesmentioning

confidence: 99%

Nucleus Pulposus‐Targeting Nanocarriers Facilitate Mirna‐Based Therapeutics for Intervertebral Disc Degeneration

Chen,

Liao,

Liu

et al. 2023

Adv Healthcare Materials

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“…[52] As for immunogenic death (ICD), after stimulation by its inducers, tumor cells will expose calreticulin (CRT) on the plasm membrane, secret adenosine triphosphate (ATP), and release the nuclear protein high-mobility group box 1 (HMGB1), which ultimately triggers a systemic anti-tumor immune response. [52,53] Therefore, cytotoxic drugs induce ICD to determine the long-term anti-tumor efficacy.…”

Section: Immunogenic Death Induced By Tc@ch-ms Therapymentioning

confidence: 99%

Piezo‐Activated Atomic‐Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound‐Triggered Schottky Electric Field

Song

Zhou

et al. 2022

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Monolayer molybdenum disulfide (MoS2) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain. However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2, quenching of piezo‐generated charges, and monotherapy. Herein, chitosan‐exfoliated monolayer MoS2 (Ch‐MS) is composited with atomic‐thin MXene, Ti3C2 (TC), to self‐assemble a multimodal nanoplatform, Ti3C2‐Chitosan‐MoS2 (TC@Ch‐MS), for tumor inactivation. TC@Ch‐MS not only inherits piezoelectricity from monolayer MoS2, but also maintains remarkable stability. Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron–hole pairs and endowing TC@Ch‐MS increase‐sensitivity magnetic resonance imaging responding. Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2O2 in the tumor microenvironment under mechanical vibration. TC@Ch‐MS possesses the superior photothermal conversion efficiency than pristine TC under near‐infrared ray illumination, attributed to its enhanced interlaminar conductivity. Meanwhile, TC@Ch‐MS realizes optimized efficiency on tumor apoptosis with immunotherapy. Therefore, TC@Ch‐MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible. This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.

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Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies

Cited by 2 publications

References 113 publications

Nucleus Pulposus‐Targeting Nanocarriers Facilitate Mirna‐Based Therapeutics for Intervertebral Disc Degeneration

Nucleus Pulposus‐Targeting Nanocarriers Facilitate Mirna‐Based Therapeutics for Intervertebral Disc Degeneration

Piezo‐Activated Atomic‐Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound‐Triggered Schottky Electric Field

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