Firm Papules on Lower Extremities of 52-Year-Old Male

Wolgamot, Gregory M.; Olerud, John E.; Argényi, Zsolt B.

doi:10.1097/01.dad.0000183541.45526.fc

Cited by 1 publication

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“…Specific skin lesions are rare and include cutaneous macroglobulinosis and a bullous dermatosis induced by the anti‐basement membrane activity of monoclonal immunoglobulin. Cutaneous macroglobulinosis is characterized by translucent, flesh‐colored papules on extensor sites 25 . Large deposits of amorphous, hyaline eosinophilic material fill the papillary and upper reticular dermis and encase blood vessels and hair follicles (Fig.…”

Section: Disorders Because Of Deposition Of M‐proteinmentioning

confidence: 99%

The histological and pathogenetic spectrum of cutaneous disease in monoclonal gammopathies

2008

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The dermatological disorders associated with monoclonal gammopathies are clinically heterogeneous and may be divided into four groups with distinctive pathogenetic mechanisms (a) specific (infiltrative) disorders including primary and secondary cutaneous plasmacytoma and cutaneous lymphoplasmacytic infiltration of Waldenström's disease (b) skin disorders because of the deposition of monoclonal immunoglobulin (M protein), including amyloidoisis macroglobulinemia cutis, light chain deposition of Randall's disease, follicular spicules of the nose, and cryoglobulinemia (c) skin disorders associated with monoclonal gammopathies, including highly associated (>50%), weakly associated (<50%) or anecdotal and (d) miscellaneous (non specific). In most cases, histopathology is crucial to confirm or to diagnose those skin conditions and is also very useful to understand their pathogenetic mechanisms.

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Section: Disorders Because Of Deposition Of M‐proteinmentioning

confidence: 99%