First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner

Ishii, K.; Kikuchi, Y.; Matsuyama, S.; Kanai, Yasukazu; Kotani, Kyosuke; Itô, Tatsuya; Yamazaki, H.; Funaki, Y.; Iwata, Ren; Itoh, M.; Yanai, Kazuhiko; Hatazawa, Jun; Itoh, Naoyuki; Tanizaki, Naoaki; Amano, D.; Yamada, Masato; Yamaguchi, Takashi

doi:10.1016/j.nima.2007.03.018

Cited by 56 publications

(27 citation statements)

References 9 publications

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“…15 In addition, the present method can be utilized for PET imaging systems with different detectors such as high purity Ge detectors, which have been used to improve the spatial resolution down to 1 mm. 9 We propose that the present method based on the quantum correlation of γ ray photons is not only simple but also universally applicable for any PET imaging system with different scintillators, detectors, application specific integrated circuits (ASICs), and so on.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of molecular sensitivity in positron emission tomography with quantum correlation of γ-ray photons

Sato

Kobayashi

2015

Review of Scientific Instruments

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Enhancement of molecular sensitivity in positron emission tomography (PET) has long been discussed with respect to imaging instrumentation and algorithms for data treatment. Here, the molecular sensitivity in PET is discussed on the basis of 2-dimensional coincident measurements of 511 keV γ ray photons resultant from two-photon annihilation. Introduction of an additional selection window based on the energy sum and difference of the coincidently measured γ ray photons, without any significant instrumental and algorithmic changes, showed an improvement in the signal-to-noise ratio (SNR) by an order of magnitude. Improvement of performance characteristics in the PET imaging system was demonstrated by an increase in the noise equivalent count rate (NECR) which takes both the SNR and the detection efficiency into consideration. A further improvement of both the SNR and the NECR is expected for the present system in real clinical and in-vivo environments, where much stronger positron sources are employed.

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Section: Resultsmentioning

confidence: 99%

Enhancement of molecular sensitivity in positron emission tomography with quantum correlation of γ-ray photons

Sato

Kobayashi

2015

Review of Scientific Instruments

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“…Acute radiation injury in mice will occur at this dose, and longitudinal studies are not possible under these conditions. We administered this dose for the following reasons: this was the first study, to our knowledge, using 124 I and the Fine-PET scanner, and the sensitivity of the Fine-PET scanner is 40 counts per second/kBq/mL (17) (one tenth that of the commercially available small-animal PET system). In future studies, we will conduct a longitudinal analysis of gene expression with a lower injected dose of 124 I.…”

Section: Discussionmentioning

confidence: 99%

“…The field-of-view diameter is 64 mm, and its axial length is 26 mm. The energy window setting was 250 keV, open-ended (17). Six BALB/c mice (controls; age, 6 wk; weight, 22-25 g), 5 mice with arthritis and vasculitis disease (age, 16 wk; weight, 32-24 g), and 3 mice with muscular dystrophy (age, 5 wk; weight, 12-15 g) were used.…”

Section: Petmentioning

confidence: 99%

“…This resolution is sufficient for imaging studies in rats. Recently, Ishii et al developed a practical semiconductor animal PET scanner with a cadmium telluride detector (CdTe) (Fine Structure Imaging PET [Fine-PET]) (17). The Fine-PET scanner achieves a spatial resolution of 0.8 mm in FWHM within the central 20-mm diameter of the field of view and provides a high spatial resolution of less than 1 mm in FWHM, which is applicable to studies in mice.…”

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confidence: 99%

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Delivery of Na/I Symporter Gene into Skeletal Muscle Using Nanobubbles and Ultrasound: Visualization of Gene Expression by PET

Watanabe¹,

Horie²,

Funaki³

et al. 2010

J Nucl Med

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The development of nonviral gene delivery systems is essential in gene therapy, and the use of a minimally invasive imaging methodology can provide important clinical endpoints. In the current study, we present a new methodology for gene therapy-a delivery system using nanobubbles and ultrasound as a nonviral gene delivery method. We assessed whether the gene transfer allowed by this methodology was detectable by PET and bioluminescence imaging. Methods: Two kinds of reported vectors (luciferase and human Na/I symporter [hNIS]) were transfected or cotransfected into the skeletal muscles of normal mice (BALB/c) using the ultrasound-nanobubbles method. The kinetics of luciferase gene expression were analyzed in vivo using bioluminescence imaging. At the peak of gene transfer, PET of hNIS expression was performed using our recently developed PET scanner, after 124 I injection. The imaging data were confirmed using reverse-transcriptase polymerase chain reaction amplification, biodistribution, and a blocking study. The imaging potential of the 2 methodologies was evaluated in 2 mouse models of human pathology (McH/lpr-RA1 mice showing vascular disease and C57BL/10-mdx Jic mice showing muscular dystrophy). Results: Peak luciferase gene activity was observed in the skeletal muscle 4 d after transfection. On day 2 after hNIS and luciferase cotransfection, the expression of these genes was confirmed by reverse-transcriptase polymerase chain reaction on a muscle biopsy. PET of the hNIS gene, biodistribution, the blocking study, and autoradiography were performed on day 4 after transfection, and it was indicated that hNIS expression was restricted to the site of plasmid administration (skeletal muscle). Similar localized PET and 124 I accumulation were successfully obtained in the diseasemodel mice. Conclusion: The hNIS gene was delivered into the skeletal muscle of healthy and disease-model mice by the ultrasound-nanobubbles method, and gene expression was successfully visualized with PET. The combination of ultrasound-nanobubble gene transfer and PET may be applied to gene therapy clinical protocols.

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“…Depth of interaction can be easily measurement with adequate electrode segmentation, thus enabling homogeneous spatial resolution inside the field of view. As a result there has been an increasing interest for Cd(Zn)Te detectors for μPET application [3], [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Experimental evaluation of a high resolution CdTe-based PET system

Montémont

Comtat

d’Aillon

et al. 2009

2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)

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Small animal PET imaging requires both high resolution and high sensitivity in order to detect small amounts of radiopharmaceutical with precision. Semiconductor detector such as cadmium telluride (CdTe) makes it possible to localize gamma ray interactions in 3D at submillimetric scale, enabling the design of PET system architectures with innovative geometries.Indeed, thank to a good knowledge of the depth of interaction (DOI) inside the detection unit, it becomes achievable to obtain a homogeneous spatial resolution in the whole field of view (FOV) and then to maximize the solid angle coverage, and then the lineof-response (LOR) coverage.We are developing a CdTe PET detection module, based on the stacking of individual detectors, associated with read-out ASICs. To validate experimentally this design, a small test bench featuring two detection heads was built. A dedicated electronics associating the readout ASIC and FPGA-based processing boards was developed. Experiments were carried out with point sources (using 200 micrometer capillary tubes) phantoms. Results show the potential of this technology to achieve homogeneous spatial resolution in the whole field of view.

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First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner

Cited by 56 publications

References 9 publications

Enhancement of molecular sensitivity in positron emission tomography with quantum correlation of γ-ray photons

Enhancement of molecular sensitivity in positron emission tomography with quantum correlation of γ-ray photons

Delivery of Na/I Symporter Gene into Skeletal Muscle Using Nanobubbles and Ultrasound: Visualization of Gene Expression by PET

Experimental evaluation of a high resolution CdTe-based PET system

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