IntroductionThe association between viral infections and pulmonary exacerbations in children with cystic fibrosis (cwCF) is well established. However, the question of whether cwCF are at a higher risk of COVIDâ19 or its adverse consequences remains controversial.MethodsWe conducted an observational, multicenter, crossâsectional study of cwCF infected by severe acute respiratory syndrome coronavirusâ2 (SARSâCoVâ2) between March 2020 and June 2022, (first to sixth COVIDâ19 pandemic waves) in Spain. The study aimed to describe patients' basal characteristics, SARSâCoVâ2 clinical manifestations and outcomes, and whether there were differences across the pandemic waves.ResultsDuring study time, 351 SARSâCoV2 infections were reported among 341 cwCF. Median age was 8.5 years (range 0â17) and 51% were female. Cases were unevenly distributed across the pandemic, with most cases (82%) clustered between November 2021 and June 2022 (sixth wave, also known as Omicron Wave due to the higher prevalence of this strain in that period in Spain). Most cwCF were asymptomatic (24.8%) or presented with mild Covidâ19 symptoms (72.9%). Among symptomatic, most prevalent symptoms were fever (62%) and increased cough (53%). Infection occurring along the sixth wave was the only independent risk factor for being symptomatic. Just eight cwCF needed hospital admission. No multisystem inflammatory syndrome, persisting symptoms, longâterm sequelae, or deaths were reported.ConclusionsSpanish current data indicate that cwCF do not experience higher risks of SARSâCoVâ2 infection nor worse health outcomes or sequelae. Changes in patients' basal characteristics, clinical courses, and outcomes were detected across waves. While the pandemic continues, a worldwide monitoring of COVIDâ19 in pediatric CF patients is needed.