First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke

Ebersberger, Louise; Kratzer, Fabian J.; Potreck, Arne; Niesporek, Sebastian C.; Keymling, Myriam; Nagel, Armin M.; Bendszus, Martin; Wick, Wolfgang; Ladd, Mark E.; Hoffmann, Angelika; Platt, Tanja; Paech, Daniel

doi:10.3389/fnins.2023.1186558

Cited by 1 publication

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“…In accordance with the Warburg effect, a reduction of oxidative glycolysis could be shown for both, high- and low-grade glioma [ 13 ]. Recently, dynamic 17 O MRI has been applied to a patient with early subacute stroke, not showing any significant difference between the stroke region and the mirrored healthy contralateral side, but motivating the application of this modality to patients with larger strokes [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain

Ebersberger,

Kratzer,

Franke

et al. 2023

Magn Reson Mater Phy

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Objective First implementation of dynamic oxygen-17 (17O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain. Methods Five healthy volunteers underwent a three-phase 17O gas (17O2) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17O water (H217O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm. Results The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17O MR data resulted in high signal fluctuations with a noise level of 10% due to small regions of interest (ROI), impeding further quantitative analysis. Statistical evaluation of the relative H217O signal with PV correction (p = 0.168) and without (p = 0.382) did not show significant difference between the stimulated left and non-stimulated right sensorimotor ROI. Discussion The change of cerebral oxygen metabolism induced by sensorimotor and visual stimulation is not large enough to be reliably detected with the current setup and methodology of dynamic 17O MRI at 7 T.

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Section: Introductionmentioning

confidence: 99%