First Attack of Acute Urticaria in Pediatric Emergency Department

Liu, Tzu-Hsuan; Lin, Yan Ren; Yang, Kuo‐Chia; Chou, Chu-Chung; Chang, Yu-Jun; Wu, Han-Ping

doi:10.1016/s1875-9572(08)60014-5

Cited by 55 publications

(53 citation statements)

References 11 publications

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“…The most common etiologic factors in children with acute urticaria include acute infections, food, insect bites, and parasitic infections, respectively (11,14,(17)(18)(19). In our study, the triggering factors we found were similar to those in many studies in the literature.…”

Section: Discussionsupporting

confidence: 87%

“…Similarly, no significant difference was found in terms of sex in children with acute and chronic urticaria by Chang et al (10), in children with acute urticaria who presented to emergency department by Liu et al (11), or in children with food-induced urticaria by Wananukul et al (12). However, urticaria is observed more frequently in adult women compared with adult men (3).…”

Section: Discussionmentioning

confidence: 99%

“…Acute urticaria was observed more fre- Acute urticaria Chronic urticaria 0-3 4-6 7-9 10-12 13-15 [16][17][18] Age quently in children aged below ten years and chronic urticaria was observed more frequently in children aged 10 years and older. In the literature, the age range is 3-8 years for acute urticaria and 8.8-10.4 years for chronic urticaria in childhood (10,11,(13)(14)(15). The main reasons for the age difference between the two diseases may include triggering of acute urticaria, mostly by external factors; a shorter time period required for occurrence of symptoms in acute urticaria; development of chronic urticaria over a longer time period; and presence of autoimmune mechanisms in chronic urticaria.…”

Section: Discussionmentioning

confidence: 99%

“…The success of specifying triggering factors in urticaria ranges between 21% and 83% in different studies (10)(11)(12)(13)(14)(15)(16). In our study, we found no factors that could lead to urticaria in approximately one fifth of the children with acute urticaria, and in approximately half of the children with chronic urticaria.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the triggering factors we found were similar to those in many studies in the literature. The rate of specifying the triggering factors in urticaria ranges between 12.4% and 17% in different studies (11,19,20). It is very difficult to differentiate etiologic factors in urticaria that occurs after use of medication during acute infection in children.…”

Section: Discussionmentioning

confidence: 99%

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High-dose anti-histamine use and risk factors in children with urticaria

Uysal¹,

Avcıl²,

Erge³

2016

Turk Pediatri Ars

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Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria. Material and Methods:The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria. Results:The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p<0.0001). There was no difference between the two groups in terms of blood eosinophil and basophil counts, and serum total IgE levels (p>0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=-0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged ≥10 years (p<0.001, p=0.015). High UAS7 score (OR: 1.09; CI 95%: [1.03-1.15]) and basopenia (OR: 6.77; CI 95%: [2.01-22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria. Conclusion:The requirement of high-dose H1-antihistamines was higher with children's increasing age. Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines. (Turk Pediatri Ars 2016; 51: 198-203)

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