First booster dose uptake of COVID-19 vaccine and disease-related factors in chronic obstructive pulmonary disease—a cross-sectional survey in Hungary

Abstract

Background: In chronic obstructive pulmonary disease (COPD), uptake of the coronavirus disease 2019 (COVID-19) booster vaccine is important, as they are more likely to develop serious complications. Our aim was to investigate the uptake rate of first booster vaccination against COVID-19 among COPD patients and to identify other related factors of vaccine uptake. Methods: We conducted a multicenter survey of COPD patients in Hungary by region: eastern, western and central ones from 15 November 2021. Respiratory function test results, anthropometric data and vaccination status were recorded for 1510 randomly selected patients over 35 years of age. Multiple logistic regression analysis was used to determine factors associated with uptake of COVID-19 first booster dose vaccines.Results: The average age was 67 [61-72] years, for men it was: 67 [62-73] and 66 [60-72] years for women, with a sample of 47.95% men and 52.05% women. The uptake rate of the COVID-19 first booster vaccine during the study period was 62.45%. Comparing patients who received the 3rd vaccine with those who did not receive the 3rd vaccine, the difference was significant in quality of life: COPD Assessment Test (CAT):16 [11][12][13][14][15][16][17][18][19][20][21] vs. 14 [10-19], P<0.001, modified Medical Research Council (mMRC) dyspnea scale: 2 [2-2] vs. 2 [1-2], P=0.01 and in the number of moderate exacerbations: 1 [0-1] vs. 0 [0-1], P=0.04. In addition, who did not take the third vaccination significantly more people were hospitalized for acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (16 vs. 0, P<0.001) and almost the same proportion (n=14) required pulmonary outpatient rehabilitation for post-COVID symptoms. The factors that were most associated with higher COVID-19 vaccine first booster dose uptake were older age [odds ratio (OR): 1.06; 95% confidence interval (CI): 1.04-1.08], male gender (OR: 0.74; 95% CI: 0.57-0.96), absence of previous COVID-19 infection (OR: 0.34; 95% CI: 0.23-0.51). Conclusions:The uptake rate of the COVID-19 booster vaccine among COPD patients in Hungary is lower than the target, and is associated with disease-related factors, and age, sex, previous COVID infection.The global COVID-19 vaccination target is 70% and 100% for elderly, vulnerable patients. Highlighting the importance of taking booster vaccine(s) should be a priority for health workers.

The Prevalence and Determinants of Hesitancy for Regular COVID-19 Vaccination among Primary Healthcare Patients with Asthma or COPD in Greece: A Cross-Sectional Study

“…Based on a previous publication [33] and the relevant literature [25][26][27][28][29], a structured questionnaire was developed (Supplementary File S1). The questionnaire consisted of questions from different categories: (1) socio-demographic factors, such as age, gender, marital status, and educational background; (2) factors influencing health status, including smoking habits, previous medical conditions, self-assessed health, vulnerability level, and the vulnerability of family members; (3) information on their COVID-19 vaccination status, including the number of doses received and any side effects reported; (4) willingness to receive additional (booster) doses of the vaccine (yes/no); (5) attitudes and beliefs regarding the COVID-19 vaccine (20 items with questions of agreement or disagreement); (6) level of knowledge and questions about the impact of various factors on vaccine participation, such as religion, politics, science, media, and the anti-vaccine movement and whether they had received the influenza vaccination during the previous season; and (7) concerns regarding the possibility of getting infected with COVID-19.…”

“…Nevertheless, there is limited information regarding patients with COPD or asthma who hesitate to receive regular COVID-19 vaccinations. One recent study showed that the coverage of COVID-19 booster vaccination among patients with COPD was less optimal (62.45%) [29] than the target of 70% suggested by the World Health Organization (WHO) [30]. To the best of our knowledge, there have been no reports on the coverage of COVID-19 booster vaccinations among patients with asthma.…”