First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: Case report and review of the literature

Abstract

Spermatocytic Seminoma (SS) is less common than the Classic variant, as its incidence ranges between 1.3% and 2.3% of all seminomas. Generally SS is diagnosed in men older than 50 years. The Anaplastic variant of Spermatocytic Seminoma is characterized by an earlier onset when compared to SS, but a benign behavior in spite of its histological patterns similar to Classic Seminoma. We reported the first case of bilateral, largest and synchronous Anaplastic Spermatocytic Seminoma, in a patient treated with radical orchifunicolectomy alone and with long-term follow-up. The currently available data show that Anaplastic SS reveals a clinically benign behavior, and no distant metastases have been reported so far. A close surveillance after surgery could be considered a valid option in the management of this rare testicular neoplasm.

Predicting Gonadal Germ Cell Cancer in People with Disorders of Sex Development; Insights from Developmental Biology

“…The spermatocytic (Type III) GCTs were historically diagnosed as spermatocytic seminoma, based on the assumed similarities to seminoma [53], now simply renamed as spermatocytic tumor in the WHO 2016 classification system [5]. They are predominantly found in elderly men and their pathogenesis has been elucidated in large detail [53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68]. The cell of origin is either a spermatogonium or spermatocyte, in line with their cellular composition, RNA, and protein profile.…”