First Case of Cutaneous Reconstitution Inflammatory Syndrome Associated with HIV Infection and Leishmaniasis

Kérob, Delphine; Bouaziz, J.‐D.; Sarfati, C.; Pavie, Juliette; Vignon‐Pennamen, Marie‐Dominique; Menotti, Jean; Hamane, Samia; Pralong, François P.; Buffet, Pierre; Morel, P; Lebbe, Célèste

doi:10.1086/506572

Cited by 15 publications

(9 citation statements)

References 11 publications

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“…Diagnoses of disease due to Leishmania braziliensis were established in both patients and both responded well to treatment with either amphotericin B or pentavalent antimony [23]. One further report describes a Senegalese patient with cutaneous leishmaniasis due to Leishmania major [24 ]. This initially started to respond to anti-leishmanial treatment, but during ART the patient developed multiple new subcutaneous nodules over a two-month period.…”

Section: Leishmaniasismentioning

confidence: 94%

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Immune reconstitution disease associated with parasitic infections following initiation of antiretroviral therapy

Lawn

2007

Current Opinion in Infectious Diseases

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Section: Leishmaniasismentioning

confidence: 94%

“…From a mechanistic viewpoint, one might therefore expect that IRD would be more commonly associated with these forms of disease rather than visceral disease. As yet, however, only three cases have been reported [23,24 ] ( Table 1). Posaga-Vergara et al [23] described two cases in Brazil.…”

Section: Leishmaniasismentioning

confidence: 99%

Immune reconstitution disease associated with parasitic infections following initiation of antiretroviral therapy

Lawn

2007

Current Opinion in Infectious Diseases

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“…Furthermore, first episodes of VL were described for three severely immunocompromised patients, all with undetectable viral loads, who had just started HAART (122). A few possible cases of IRD with DCL (192), CL (128), and PKDL (26,103,208) have been described.…”

Section: Ird In Leishmania-hiv Coinfectionmentioning

confidence: 99%

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

et al. 2008

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SUMMARY To date, most Leishmania and human immunodeficiency virus (HIV) coinfection cases reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of coinfection were identified, of which 90% were from Spain, Italy, France, and Portugal. However, these figures are misleading because they do not account for the large proportion of cases in many African and Asian countries that are missed due to a lack of diagnostic facilities and poor reporting systems. Most cases of coinfection in the Americas are reported in Brazil, where the incidence of leishmaniasis has spread in recent years due to overlap with major areas of HIV transmission. In some areas of Africa, the number of coinfection cases has increased dramatically due to social phenomena such as mass migration and wars. In northwest Ethiopia, up to 30% of all visceral leishmaniasis patients are also infected with HIV. In Asia, coinfections are increasingly being reported in India, which also has the highest global burden of leishmaniasis and a high rate of resistance to antimonial drugs. Based on the previous experience of 20 years of coinfection in Europe, this review focuses on the management of Leishmania-HIV-coinfected patients in low-income countries where leishmaniasis is endemic.

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“…Self-healing is less common and as there is a risk of evolution to MCL specific treatment is recommended. 147 The high frequency of relapses is the most salient feature in the treatment of HIV/Leishmania co-infection. There is only very limited experience with local treatment.…”

Section: Cutaneous Leishmaniasismentioning

confidence: 99%