First case of herpetic meningoencephalitis treated with ganciclovir

Blanc, Anne Laure; Mansouf, Loubna El; Lemaire, Xavier

doi:10.1080/1120009x.2016.1195070

Cited by 3 publications

(1 citation statement)

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“…As bacterial meningoencephalitis can often not be ruled out on clinical grounds, and septic encephalopathy is a common mimic of herpetic encephalopathy [12], the addition of broad-spectrum antibiotics is recommended until bacterial infection can be ruled out. This approach is supported by recent UK guidelines for the empirical management of encephalitis [13].…”

Section: Discussionmentioning

confidence: 99%

Herpes simplex virus-1 herpetic meningoencephalitis in Adults: Three cases in Casablanca, Morocco

Hassan,

Badi,

Lahrichi

et al. 2024

EMJ

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Herpes simplex virus type 1 is the first cause of acute focal encephalitis with necrosis of the cerebral parenchyma in children and adults, with high morbidity. Herpes simplex virus type 2 is the main cause of herpetic meningitis in adults, with a good evolution. Herpetic meningoencephalitis is rarely caused by HSV-1. We report three observations of PCR-confirmed HSV-1 meningoencephalitis in cerebrospinal fluid in young immunocompetent adults aged 27, 53, and 58. They presented with a meningoencephalitis picture consisting of a meningeal syndrome and encephalic involvement. Lumbar puncture confirmed lymphocytic clear-fluid meningitis, with a median white blood cell count of 97, red blood cell count of 69, proteinorachia of 0.78, and glycorachia of 0.62. Cerebral magnetic resonance imaging is the gold-standard neuroimaging technique in the management of herpetic meningoencephalitis. Early initiation of acyclovir has contributed significantly to improved patient outcomes and prognosis. Herpetic meningoencephalitis is a diagnostic and therapeutic emergency, with a very poor functional prognosis, particularly in terms of complications.

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Section: Discussionmentioning

confidence: 99%