First case of human bacteraemia by Catabacter hongkongensis in Scandinavia

Abstract

Catabacter hongkongensis was isolated and cultured from human blood for the first time in Scandinavia. The patient, an 83-year-old man from Dalarna, Sweden, recovered without antibiotic treatment, although a high mortality rate associated with C. hongkongensis infection had been reported from China, Canada and France. The genome of the strain ABBA15k was sequenced, assembled and analysed. In contrast to the type strain of the species HKU16T, no antibiotic resistance was observed in Scandinavian strain ABBA15k. The strain was deposited as CCUG 68271, and the draft genome sequence is available from the DNA Data Bank of Japan (DDBJ), the European Molecular Biology Laboratory (EMBL), and GenBank under the accession number LLYX00000000.

Reclassification of Catabacter hongkongensis as Christensenella hongkongensis comb. nov. based on whole genome analysis

“…hongkongensis HKU16 T , and the genes coding for chemotaxin ( cheA ) and flagellar assembly ( flhA and MotA ) were not present in the genome of C. hongkongensis ABBA15k [34]. The tetracycline resistance gene tet was detected in the genome of C.…”

“…hongkongensis HKU16T, but no resistance genes were detected in the genome of C. hongkongensis ABBA15k [34].…”

“…Strain ABBA15k showed 100 % pairwise 16S rRNA gene identity with Catabacter hongkongensis HKU16 T . However, the genome of C. hongkongensis ABBA15k is smaller than C. hongkongensis HKU16 T , and the genes coding for chemotaxin ( cheA ) and flagellar assembly ( flhA and MotA ) were not present in the genome of C. hongkongensis ABBA15k [ 34 ]. The tetracycline resistance gene tet was detected in the genome of C. hongkongensis HKU16T, but no resistance genes were detected in the genome of C. hongkongensis ABBA15k [ 34 ].…”

Reclassification ofCatabacter hongkongensisasChristensenella hongkongensiscomb.nov. based on whole genome analysis

“…isolates are reported to be motile and resistant to cefotaxime [1,2,5,32] except for C. hongkongensis ABBA15k , which was isolated in 2016 from the blood of a patient with a fever in Sweden [33]. Strain ABBA15k showed 100% 16S rRNA gene identity with Catabacter hongkongensis HKU16 T .…”

“…ABBA15k [33]. The tetracycline resistance gene tet was detected in the genome of C. hongkongensis HKU16 T , but no resistance genes were detected in the genome of C. hongkongensis ABBA15k [33]. The detailed information about AMR genes is listed in Table 2.…”