First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Melo‐Cristino, José; Resina, Cristina; Manuel, Viviana; Lito, Luı́s; Ramírez, Mario

doi:10.1016/s0140-6736(13)61219-2

Cited by 104 publications

(74 citation statements)

References 4 publications

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“…Full genome sequencing of VRSA isolates has been described (59,60). A VRSA isolate was also recently identified in Portugal, also in the diabetic wound of a patient (61). Additional reports from other parts of the world have not yet been confirmed.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of vancomycin resistance in Staphylococcus aureus

Gardete¹,

Tomasz²

2014

J. Clin. Invest.

447

306

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Section: Introductionmentioning

confidence: 99%

Mechanisms of vancomycin resistance in Staphylococcus aureus

Gardete¹,

Tomasz²

2014

J. Clin. Invest.

447

306

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“…8 Vancomycin is prescribed for the treatment of MRSA infections, 8 however, the emergence of vancomycin-resistant Staphylococcus aureus was reported. 9,10 Therefore, the treatment other than antibiotic therapy is demanded. Shin'iseihaito (xinyiqingfeitang in Chinese, SSHT) is a formula in traditional Japanese Kampo medicine and Chiniese medicine to treat sinusitis associated with lung-heat syndrome, which is characterized by the symptoms of purulent nasal discharge, reddish nasal mucosa, and so on.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity Of Shin’iseihaito (Xinyiqingfeitang) And its Components Against Methicillin-Resistant Staphylococcus aureus

Konishi¹,

Minami²,

Makino³

2017

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Objective: Shin'iseihaito (xinyiqingfeitang in Chinese, SSHT), a formula in traditional Japanese Kampo medicine and Chinese medicine comprising nine crude drugs, Gypsum, Ophiopogon Tuber, Scutellaria Root (SR, root of Scutellaria baicalensis), Gardenia Fruit, Anemarrhena Rhizome, Lilium Bulb, Magnolia Flower, Loquat Leaf, and Cimicifuga Rhizome (CR, rhizome of Cimicifuga heracleifolia), is commonly used to treat sinusitis associated with purulent nasal discharge and reddish nasal mucosa. We evaluated anti-bacterial activity of SSHT extract on methicillin-resistant Staphylococcus aureus (MRSA), one cause of bacterial sinusitis. Materials and Methods: Sterile paper disks impregnated with SSHT extract, the combination of crude drugs composing SSHT according to the traditional pharmacological theory, or each component were placed on Mueller-Hinton agar plates inoculated with several strains of MRSA isolated from the patients. The diameter of inhibitory zone was measured after 18-24 h incubation. Results: SSHT extract showed antibacterial activity against 128/190 (66.8%) MRSA clinical isolates. The effect of the extract of SSHT without heat-clearing drugs (SSHT-HC) or without exterior-releasing drugs (SSHT-ER) were significantly lower than that of SSHT extract. Each water extract of SR, Loquat Leaf, Magnolia Flower and CR showed significant anti-MRSA activity, and SR extract exhibited the largest inhibitory zone. Conclusions: SSHT has antibacterial activity against MRSA clinical isolates, and SR mainly contributes to the antibacterial activity of SSHT against MRSA clinical isolates.

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“…Thirty five cases of VRSA infection have been reported worldwide by May 2016, including 1 from Pakistan, 3 from Iran, 14 from the USA, 16 from India, and 1 from Portugal [12][13][14].…”

Section: Introductionmentioning

confidence: 99%