First case of mycetoma associated with <i><scp>N</scp>ocardia takedensis</i>

Kresch-Tronik, Nicole S.; Carrillo-Casas, Erika M.; Arenas, Roberto; Atoche, Carlos; Río-Ávila, Carolina Del; Ochoa-Carrera, Luis A.; Martínez‐Hernández, Fernando; Xicohtencatl‐Cortes, Juan; Leyva-Leyva, Margarita; Hernández‐Castro, Rigoberto

doi:10.1111/1346-8138.12009

Cited by 11 publications

(11 citation statements)

References 5 publications

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“…Molecular biology techniques such as PCR and sequencing of 16S rRNA and the hsp65 gene allow the correct identification and classification of Nocardia species [13]. For example, N. mexicana , N. harenae , and N. takedensis were isolated from Mexican patients [34], [35], [36]. The second most common causative agent was A. madurae ; distributed worldwide [11], which is easily identified due to the larger (1–3 mm) white-yellowish, soft, wide-fringed border grains.…”

Section: Discussionmentioning

confidence: 99%

Mycetoma: Experience of 482 Cases in a Single Center in Mexico

et al. 2014

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Mycetoma is a chronic granulomatous disease. It is classified into eumycetoma caused by fungi and actinomycetoma due to filamentous actinomycetes. Mycetoma can be found in geographic areas in close proximity to the Tropic of Cancer. Mexico is one of the countries in which this disease is highly endemic. In this retrospective study we report epidemiologic, clinical and microbiologic data of mycetoma observed in the General Hospital of Mexico in a 33 year-period (1980 to 2013). A total of 482 cases were included which were clinical and microbiology confirmed. Four hundred and forty four cases (92.11%) were actinomycetomas and 38 cases (7.88%) were eumycetomas. Most patients were agricultural workers; there was a male predominance with a sex ratio of 3∶1. The mean age was 34.5 years old (most ranged from 21 to 40 years). The main affected localization was lower and upper limbs (70.74% and 14.52% respectively). Most of the patients came from humid tropical areas (Morelos, Guerrero and Hidalgo were the regions commonly reported). The main clinical presentation was as tumor-like soft tissue swelling with draining sinuses (97.1%). Grains were observed in all the cases. The principal causative agents for actinomycetoma were: Nocardia brasiliensis (78.21%) and Actinomadura madurae (8.7%); meanwhile, for eumycetomas: Madurella mycetomatis and Scedosporium boydii (synonym: Pseudallescheria boydii) were identified. This is a single-center, with long-follow up, cross-sectional study that allows determining the prevalence and characteristics of mycetoma in different regions of Mexico.

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Section: Discussionmentioning

confidence: 99%

Mycetoma: Experience of 482 Cases in a Single Center in Mexico

et al. 2014

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“…N. takedensis was isolated from a biopsy of foot tissue8. The second case was a healthy 33-year-old man in Mexico who presented with hemithoracic actinomycetoma9. The last case was a 68-year-old woman with a history of follicular lymphoma and myelodysplastic syndrome after allogenic peripheral blood stem cell transplantation who presented with painful lymphangitic erythematous papules on the left arm after suffering an abrasion on the left dorsal hand7.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Nocardiosis Caused by Nocardia takedensis

et al. 2017

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Nocardia species are aerobic, gram-positive, filamentous, partially acid-fast actinomycetes which are found worldwide in soil and decaying organic plant matter. When they infect human beings, they generally enter through the respiratory tract and then disseminate systemically. Rarely has a primary infection occurred as the result of direct inoculation. Isolation of Nocardia from clinical specimens and identification of species are difficult. But, with the introduction of new genetic technologies, reports of novel species of Nocardia have increased. We describe a case of cutaneous nocardiosis caused by Nocardia takedensis in an 87-year-old woman who was diagnosed by bacterial culture and 16S ribosomal RNA sequencing. N. takedensis has been described as a new species. This report describes the first clinical isolate of N. takedensis from a skin specimen in Korea.

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“…The patient was asymptomatic, and no specific treatment was given . The fourth was a 33‐year‐old man from Yucatan, Mexico, presenting with mycetoma of the left hemithorax, who was successfully treated with a 14‐month course of TMP‐SMZ and dapsone . The last case was a 68‐year‐old‐woman with a follicular lymphoma and myelodysplastic syndrome treated by allogeneic peripheral blood stem cell transplantation, presenting with lymphangitic papules, who improved after cefuroxime and amoxicillin/clavulanate completed with 7 days of TMP‐SMZ …”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous nocardiosis caused by Nocardia takedensis with pulmonary dissemination in an immunosuppressed patient

et al. 2016

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We present a remarkable case of primary cutaneous nocardiosis with pulmonary dissemination due to Nocardia takedensis in a 76-year-old man suffering from marginal zone lymphoma and hypogammaglobulinaemia. We also discuss an alternative treatment to trimethoprim-sulfamethoxazole, which could be contraindicated due to haematological and cutaneous toxicities. This case report is of interest due to the emergence of cutaneous nocardiosis in dermatology.

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First case of mycetoma associated with Nocardia takedensis

Cited by 11 publications

References 5 publications

Mycetoma: Experience of 482 Cases in a Single Center in Mexico

Mycetoma: Experience of 482 Cases in a Single Center in Mexico

Primary Cutaneous Nocardiosis Caused by Nocardia takedensis

Primary cutaneous nocardiosis caused by Nocardia takedensis with pulmonary dissemination in an immunosuppressed patient

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