First Case of Splenic Abscess Parvimonas micra and Bacteremia Porphyromonas gingivalis Coinfection

Ho, Angela; Duvapu, Bharati; Duong, Ngoc Q. K.; Samantara, Sandhyarani

doi:10.7759/cureus.28103

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…6 Thus far, very few cases of spleen abscess, liver abscess, post-chest wall abscess empyema, and P. gingivalis bacteremiainduced brain abscess have been reported. [7][8][9][10] There is evidence that P. gingivalis can cause bronchial and pharyngeal epithelial cells to produce proinflammatory cytokines in the absence of acute infection, leading to aspiration pneumonia. 11 However, there has been no evidence that P. gingivalis causes hematogenous disseminated severe pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis-induced hematogenous disseminated severe pneumonia: a case report

Yuanjun,

Yan,

Qingyan

et al. 2024

J Int Med Res

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Porphyromonas gingivalis, a gram-negative oral anaerobe among more than more than 500 bacterial species that colonizing the oral cavity, is involved in the pathogenesis and prototypic polybacterial consortium of periodontitis. It is mainly found in oral infections and rarely present in other organ diseases. Here, we describe a 43-year-old man with underlying diabetes who developed hematogenous disseminated severe pneumonia after P. gingivalis had invaded the blood. Next-generation sequencing of early alveolar lavage fluid and blood samples confirmed the diagnosis. The patient’s lung infection improved after targeted antimicrobial treatment. He was successfully weaned from ventilatory support and transferred to the general ward. This case illustrates bacterial entry into the bloodstream of a patient with diabetes who had periodontal disease but did not maintain oral hygiene, leading to severe pneumonia. Periodontal disease is often ignored by the public, and it is difficult for critical care physicians to link severe pneumonia with periodontal disease. Thus, this case represents an important warning to critical care clinicians.

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Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis-induced hematogenous disseminated severe pneumonia: a case report

Yuanjun,

Yan,

Qingyan

et al. 2024

J Int Med Res

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“…Its habitat encompasses the skin and mucosal surfaces of the oral cavity, upper respiratory tract, gastrointestinal tract, and the female genitourinary tract ( 1 , 2 ). Parvimonas micra is implicated as the causative agent in a spectrum of ailments, ranging from sternum osteomyelitis ( 3 ), and femur osteomyelitis ( 4 ), to sepsis ( 5 ), endocarditis ( 5 ), hepatic abscesses ( 6 , 7 ), and even fatal outcomes ( 1 ). Notably, P. micra predominantly affects immunocompromised hosts ( 8 , 9 ) with infected individuals often presenting underlying risk factors such as oral infections, diabetes mellitus, and malignant tumors ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Hemoptysis caused by Parvimonas micra: case report and literature review

Shao,

He,

Jiao

et al. 2024

Front. Public Health

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BackgroundParvimonas micra (P. micra), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for P. micra-related diseases encounters delays, often with severe consequences, including fatality, attributed to the absence of symptom specificity and challenges in culture. The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. This study aims to elucidate and scrutinize the clinical manifestations linked to P. micra, drawing insights from an extensive literature review of pertinent case reports.Case presentationA 53-year-old male sought medical attention at our institution presenting with recurrent hemoptysis. Empirical treatment was initiated while awaiting pathogen culture results; however, the patient’s symptoms persisted. Subsequent metagenomic next-generation sequencing (mNGS) analysis revealed a pulmonary infection attributable to P. micra. Resolution of symptoms occurred following treatment with piperacillin sulbactam sodium and moxifloxacin hydrochloride. A comprehensive literature review, utilizing the PubMed database, was conducted to assess case reports over the last decade where P. micra was identified as the causative agent.ConclusionThe literature analysis underscores the predilection of P. micra for immunocompromised populations afflicted by cardiovascular diseases, diabetes, orthopedic conditions, and tumors. Risk factors, including oral and periodontal hygiene, smoking, and alcohol consumption, were found to be associated with P. micra infections. Clinical manifestations encompassed fever, cough, sputum production, and back pain, potentially leading to severe outcomes such as Spondylodiscitis, septic arthritis, lung abscess, bacteremia, sepsis, and mortality. While conventional bacterial culture remains the primary diagnostic tool, emerging technologies like mNGS offer alternative considerations. In terms of treatment modalities, β-lactam antibiotics and nitroimidazoles predominated, exhibiting recovery rates of 56.10% (46/82) and 23.17% (19/82), respectively. This case report and literature review collectively aim to enhance awareness among clinicians and laboratory medicine professionals regarding the intricacies of P. micra-associated infections.

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First Case of Splenic Abscess Parvimonas micra and Bacteremia Porphyromonas gingivalis Coinfection

Cited by 2 publications

References 15 publications

Porphyromonas gingivalis-induced hematogenous disseminated severe pneumonia: a case report

Porphyromonas gingivalis-induced hematogenous disseminated severe pneumonia: a case report

Hemoptysis caused by Parvimonas micra: case report and literature review

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