First case report of papillary thyroid carcinoma arising within a functional teratoma in Graves’ disease patient

Cheng, Chen Chuan; Ting-An,; Chang,; Yang, Wen-Ping

doi:10.1080/09513590.2021.1943345

Cited by 2 publications

(4 citation statements)

References 10 publications

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“…7 Since then, five additional cases have been reported, but none were FTC. [8][9][10][11][12] Follicular thyroid carcinoma is more common in iodine-deficient areas. 3 Our patient lived in the Mekong Delta, Viet Nam.…”

Section: Discussionmentioning

confidence: 99%

A rare case of synchronous follicular thyroid carcinoma arising within a mature cystic ovarian teratoma and stage IV differentiated thyroid cancer in iodine-deficient area in Viet Nam

2023

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Well-differentiated thyroid carcinoma rarely spreads to soft tissues. Thyroid carcinoma arising within a mature cystic teratoma is even rarer. We report an extremely rare case of synchronous follicular thyroid carcinoma arising within a mature cystic ovarian teratoma and stage IV differentiated thyroid carcinoma. A 62-year-old woman who lived in an iodine-deficient area was accidentally diagnosed with an ovarian cyst during a radiological metastatic work-up for thyroid cancer. Following laparoscopic left salpingo-oophorectomy, histopathological examination revealed a follicular thyroid carcinoma arising within a mature cystic teratoma. After that, total thyroidectomy and surgical resection of the soft tissue lesion in the supraclavicular fossa were performed, and the patient received subsequent 131I ablation therapy, but the disease progression was recorded 3 months later. We believe that iodine deficiency plays a role in the malignant transformation of thyroid tissues within a mature cystic teratoma. In elderly individuals with significant metastases, radioactive iodine therapy is ineffective.

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Section: Discussionmentioning

confidence: 99%

A rare case of synchronous follicular thyroid carcinoma arising within a mature cystic ovarian teratoma and stage IV differentiated thyroid cancer in iodine-deficient area in Viet Nam

2023

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“…The optimal treatment of thyroid carcinoma arising within MCT is uncertain due to the rarity of the disease [ 2 , 3 ]. The treatment varies and depends on the age of the patient and the presence of metastases [ 1 , 3 , 8 ]. For women of a reproductive age, if there is no capsular invasion or metastasis, cystectomy or unilateral salpingo-oophorectomy is recommended, whereas for postmenopausal women, hysterectomy and bilateral salpingo-oophorectomy are indicated [ 1 , 3 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…The treatment varies and depends on the age of the patient and the presence of metastases [ 1 , 3 , 8 ]. For women of a reproductive age, if there is no capsular invasion or metastasis, cystectomy or unilateral salpingo-oophorectomy is recommended, whereas for postmenopausal women, hysterectomy and bilateral salpingo-oophorectomy are indicated [ 1 , 3 , 8 , 9 ]. The prognosis of early-stage thyroid carcinoma in mature ovarian teratomas is excellent following treatment [ 8 ], as in this case.…”

Section: Discussionmentioning

confidence: 99%

“…For women of a reproductive age, if there is no capsular invasion or metastasis, cystectomy or unilateral salpingo-oophorectomy is recommended, whereas for postmenopausal women, hysterectomy and bilateral salpingo-oophorectomy are indicated [ 1 , 3 , 8 , 9 ]. The prognosis of early-stage thyroid carcinoma in mature ovarian teratomas is excellent following treatment [ 8 ], as in this case. On the other hand, stromal luteoma is a very rare tumor of the ovary that constitutes about 25% of all steroid cell tumors.…”

Section: Discussionmentioning

confidence: 99%

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Papillary thyroid carcinoma arising from a mature ovarian teratoma coexisting with stromal luteoma: the first case report in the literature

Al-janabi,

Khaddour,

Salloum

2023

Journal of Surgical Case Reports

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Mature cystic teratomas are the most common ovarian tumors in women of reproductive age. The malignant transformation of mature cystic teratomas is a rare entity. The most common malignant tumor in mature cystic teratomas is squamous cell carcinoma, whereas papillary thyroid carcinoma is an exceptional event. On the other hand, stromal luteoma is an uncommon benign steroid cell tumor of the ovary that occurs mostly in postmenopausal females. The coexistence of different ovarian tumor subtypes is an extremely rare pathological event. In this report, we describe a case of papillary thyroid carcinoma arising in mature cystic teratomas coexisting with stromal luteoma. To the best of our knowledge, this is the first report in English literature. Both mature cystic teratoma (with papillary thyroid carcinoma) and stromal luteoma are very rare entities. Pathologists should be aware of malignant transformation and exclude it when investigating mature cystic teratomas, especially in older patients.

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First case report of papillary thyroid carcinoma arising within a functional teratoma in Graves’ disease patient

Cited by 2 publications

References 10 publications

A rare case of synchronous follicular thyroid carcinoma arising within a mature cystic ovarian teratoma and stage IV differentiated thyroid cancer in iodine-deficient area in Viet Nam

A rare case of synchronous follicular thyroid carcinoma arising within a mature cystic ovarian teratoma and stage IV differentiated thyroid cancer in iodine-deficient area in Viet Nam

Papillary thyroid carcinoma arising from a mature ovarian teratoma coexisting with stromal luteoma: the first case report in the literature

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