COVID-19 pandemic has created huge havoc in public health in India and across the world. One among the small states of India, Mizoram lies between Bangladesh and Myanmar compelling a transmission risk of various infectious diseases across the boundary. The responsibilities of the authority to establish a screening and diagnostic laboratory is crucial to identify the infectious etiological agents, control, prevent morbidity, mortality, and burden of the diseases. We aim to discuss the need for an infectious disease surveillance system, the importance and role of advanced diagnostic and research laboratory in Mizoram, learning from SARS-CoV-2 pandemic.