2006
DOI: 10.1021/es0606531
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First Derivation of Predicted-No-Effect Values for Freshwater and Terrestrial Ecosystems Exposed to Radioactive Substances

Abstract: The FASSET Radiation Effects Database (FRED) constitutes a unique structured resource of the biological effects of ionizing radiation on non-human species mainly from temperate ecosystems, encompassing 26,000 primary data entries. Quality-assessed data were extracted from FRED and dose-effect relationships were constructed to provide estimates of ED50 and EDR10. These estimates are Doses (or Dose Rates) related to the percent change in the average level of the endpoint for a particular effect (50% or 10% for a… Show more

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Cited by 96 publications
(55 citation statements)
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“…For radioactive substances, the primary ecotoxicity values are the Dose Rates associated with a 50% Effect defined as the percent change in the (average) level of the observed endpoint during a chronic external irradiation exposure experiment, named EDR 50 expressed in Gy/h [8]. Their geometric mean H DR 50 and associated 95% confidence interval can be easily calculated, still expressed in Gy/h.…”
Section: Working Endpoint Calculation Hc 50 and Hdr 50mentioning
confidence: 99%
See 1 more Smart Citation
“…For radioactive substances, the primary ecotoxicity values are the Dose Rates associated with a 50% Effect defined as the percent change in the (average) level of the observed endpoint during a chronic external irradiation exposure experiment, named EDR 50 expressed in Gy/h [8]. Their geometric mean H DR 50 and associated 95% confidence interval can be easily calculated, still expressed in Gy/h.…”
Section: Working Endpoint Calculation Hc 50 and Hdr 50mentioning
confidence: 99%
“…For radioactive substances, radiotoxicity values of EDR 50 come from previous work from Garnier-Laplace et al [8,11]. The 95% confidence interval on the geometric mean was calculated by bootstrap using R library [12].…”
Section: Input Data and Statisticsmentioning
confidence: 99%
“…Each dataset was substituted for regression analysis to reconstruct the dose(rate) -effect relationship and then estimate the critical exposure values that were defined the same way as in [5,6]. Thus, the dose giving 50% change in observed effect (ED 50 ) in comparison to control is considered as the critical dose for acute exposure, and the critical dose rate for chronic exposure is defined as the dose rate resulting in 10% change of observed effect (EDR 10 ).…”
Section: Dose (Rate) -Effect Modelsmentioning
confidence: 99%
“…As there is no scientific reason to discriminate between chemicals and radioactive substances in terms of environmental risk assessment methodology (ERA), it is now generally recognised [2] that the classical ERA method [1] may be applied to both of these substances. This is of particular interest in the case of uranium that presents a double ecotoxicity, chemical and radiological, leading until now to separate environmental impact and risk assessments that did not provide a global view of the ecological state of the target ecosystem.…”
Section: Introductionmentioning
confidence: 99%