First description of an Anaerobiospirillum succiniciproducens prosthetic joint infection

Schaumburg, Frieder; Dieckmann, Ralf; Schmidt-Bräkling, Tom; Becker, Karsten; Idelevich, Evgeny A.

doi:10.1016/j.nmni.2017.03.001

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…The most abundant genera identified were Anaerobiospirillum (32.5 %), Bacteroides (22.8 %), Phascolarctobacterium (17.8 %) and Megamonas (12.4 %). The genus Anaerobiospirillum consists of Gram-negative, anaerobic, spiral-shaped rods which are known to be the part of the normal gastrointestinal microbiota of dogs and cats [ 74, 75 ]. Bacteroides species are important members of the human and animal gut microbiota identified from feces (representing approximately 30 % of the cultured species) [ 76, 77 ].…”

Section: Resultsmentioning

confidence: 99%

The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut

2018

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Bifidobacterium is a diverse genus of anaerobic, saccharolytic bacteria that colonize many animals, notably humans and other mammals. The presence of these bacteria in the gastrointestinal tract represents a potential coevolution between the gut microbiome and its mammalian host mediated by diet. To study the relationship between bifidobacterial gut symbionts and host nutrition, we analyzed the genome of two bifidobacteria strains isolated from the feces of a common marmoset (Callithrix jacchus), a primate species studied for its ability to subsist on host-indigestible carbohydrates. Whole genome sequencing identified these isolates as unique strains of Bifidobacterium callitrichos. All three strains, including these isolates and the previously described type strain, contain genes that may enable utilization of marmoset dietary substrates. These include genes predicted to contribute to galactose, arabinose, and trehalose metabolic pathways. In addition, significant genomic differences between strains suggest that bifidobacteria possess distinct roles in carbohydrate metabolism within the same host. Thus, bifidobacteria utilize dietary components specific to their host, both humans and non-human primates alike. Comparative genomics suggests conservation of possible coevolutionary relationships within the primate clade.

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Section: Resultsmentioning

confidence: 99%

The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut

2018

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“…Fusobacteria was reported to be linked with colon cancer [ 44 ]. The genus Anaerobiospirillum consists of Anaerobiospirillum thomasii and Anaerobiospirillum succiniciproducens , which can cause infectious human diseases, such as bacteremia and abdominal infection [ 45 , 46 ]. Previous studies show that the genus Negativibacillus is associated with intestinal disorders and many other diseases such as obesity-related disorders and pediatric Crohn’s disease [ 47 , 48 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Peptides Relieve Transportation Stress in Ragdoll Cats by Regulating the Gut Microbiota

Yang

Wen

et al. 2023

Metabolites

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Transportation is common in cats and often causes stress and intestinal disorders. Antimicrobial peptides (AMPs) exhibit a broad spectrum of antibacterial activity, and they may have the capacity for antioxidant and immune regulation. The objective of this study was to investigate the effects of dietary supplementation with AMPs on stress response, gut microbiota and metabolites of cats that have undergone transport stress. A total of 14 Ragdoll cats were randomly allocated into 2 treatments: basal diet (CON) and a basal diet supplemented with 0.3% AMPs. After a 6-week feeding period, all cats were transported for 3 h and, then, fed for another week. The results show that the diarrhea rate of cats was markedly reduced by supplementation with AMPs throughout the trial period (p < 0.05). In addition, AMPs significantly reduced serum cortisol and serum amyloid A (p < 0.05) and increased apolipoprotein 1 after transportation (p < 0.05). Moreover, AMPs reduced the level of inflammatory factors in the serum caused by transportation stress, including tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) (p < 0.05). The AMPs enhanced the activities of glutathione peroxidase (p < 0.01) and superoxide dismutase (p < 0.05). Furthermore, cats fed AMPs had higher levels of branched chain fatty acids (BCFAs) and a relative abundance of Blautia and a lower relative abundance of Negativibacillus after transportation (p < 0.05). The serum metabolome analysis further revealed that AMPs markedly regulated lipid metabolism by upregulating cholic acid expression. In conclusion, AMP supplementation alleviated oxidative stress and inflammatory response in transportation by regulating the gut microbiota and metabolites, thereby relieving stress-induced diarrhea and supporting gut and host health in cats.

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“…Anaerobiospirillum infections are rare and this is the second reported case of this organism causing PJI, the first involving a hip prosthesis, and the first joint infection related to orthopedic injection [3].…”

Section: Discussionmentioning

confidence: 99%

Case report: Anaerobiospirillum prosthetic joint infection in a heart transplant recipient

Madden

Poulter

Crawford

et al. 2019

BMC Musculoskelet Disord

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Background We report a case of prosthetic hip joint infection in a heart transplant recipient due to Anaerobiospirillum succiniciproducens, a genus of spiral-shaped curved anaerobic gram-negative rod which colonizes the gastrointestinal tract of cats and dogs. Invasive infections in humans are rare and typically occur in immunocompromised hosts. Case presentation A 65-year-old male dog breeder with a history of rheumatoid arthritis, bilateral hip arthroplasties, and non-ischemic cardiomyopathy with a heart transplant 10 years ago presented with a three month history of progressive left hip pain and frank purulence on hip aspiration. He underwent irrigation and debridement of the left hip and one-stage revision with hardware exchange. Although gram stain and culture from synovial fluid and intraoperative cultures were initially negative, anaerobic cultures from tissue specimens later grew a spiral-shaped gram-negative rod, identified as Anaerobiospirillum spp. by 16S rRNA gene sequencing. The patient was treated with ceftriaxone 2 g daily for 6 weeks with a good response to treatment. A similar organism was unable to be isolated from culture of 2 of the patient’s dogs, however, they were thought to be the most likely source of his infection. Conclusion Anaerobiospirillum spp . should be considered in immunocompromised patients with exposure to dogs or cats who present with bacteremia, gastrointestinal infection, pyomyositis, or prosthetic joint infections, especially in cases of culture-negative or with anaerobic culture growth.

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First description of an Anaerobiospirillum succiniciproducens prosthetic joint infection

Abstract: Anaerobiospirillum succiniciproducens belongs to the normal flora of cats and dogs and can rarely infect humans. Here, we report the first case of an A. succiniciproducens prosthetic joint infection.

Cited by 11 publications

References 6 publications

The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut

The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut

Antimicrobial Peptides Relieve Transportation Stress in Ragdoll Cats by Regulating the Gut Microbiota

Case report: Anaerobiospirillum prosthetic joint infection in a heart transplant recipient

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