First detection of adiaspiromycosis in the lungs of a deer

Matsuda, Kazuo; Niki, Hinako; Yukawa, Airo; Yanagi, Mitsuhiro; Souma, Kousaku; Masuko, Takayoshi; Taniyama, Hiroyuki

doi:10.1292/jvms.15-0083

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…We diagnosed these spherules as adiaspores caused by Emmonsia sp. infection, based on their morphology, and histopathological and histochemical findings, which were similar to previous reports (Morner et al 1999, Malatesta et al 2014, Matsuda et al 2015. Unfortunately, we could not confirm the species (because of the lack of fresh-frozen lung tissue samples); however, considering the worldwide distribution, E. crescens infection is the most probable (Seyedmousavi et al 2015).…”

Section: Resultssupporting

confidence: 87%

Pulmonary adiaspiromycosis in the Eurasian beaver (Castor fiber) inhabiting Poland

Dolka¹,

Giżejewska²,

Giżejewski³

et al. 2017

Polish Journal of Veterinary Sciences

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Adiaspiromycosis is a rare fungal infection caused by saprophytic fungi Emmonsia spp. (type Ascomycota) occurring especially in small free-living mammals. The aim of this study was to evaluate the occurrence of histopathological lesions asscociated with adiaspiromycosis in the Eurasian beaver inhabiting Poland. In order to evaluate the presence of natural adiaspiromycosis we systematically investigated beaver populations from north-eastern Poland for adiaspores in the lungs. This study reveals for the first time the presence of pulmonary adiaspiromycosis of Eurasian beaver in Poland. As far as we know, there is no published data regarding pulmonary adiaspiromycosis in human patients in Poland.

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Section: Resultssupporting

confidence: 87%

Pulmonary adiaspiromycosis in the Eurasian beaver (Castor fiber) inhabiting Poland

Dolka¹,

Giżejewska²,

Giżejewski³

et al. 2017

Polish Journal of Veterinary Sciences

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“…Subsequently, we observed adiaspore development in mice lungs. Adiaspores in mice were observed in the lung only, which is consistent with cases of wild animals reported earlier [5,6,8].…”

Section: Discussionsupporting

confidence: 91%

“…Emmonsia crescens (Ajellomyces crescens), a dimorphic fungus found in soil worldwide [1], is known to be the causative agent of adiaspiromycosis, a pulmonary disease causing granulomatous lesions in humans [2] and animals, especially in small mammals [1][2][3][4][5][6][7] and rarely in large animals [8,9]. Although the prevalence of adiaspiromycosis in animals remains unknown, Borman reported adiaspiromycosis in 28.7% of free-living wild mammals from the southwestern UK [10].…”

Section: Introductionmentioning

confidence: 99%

Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model

Takeshige

Nakano

Kondoh

et al. 2020

Vet Res

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Lesions of adiaspiromycosis, a respiratory disease affecting wild animals, have been found mainly in dead mammals and free-living mammals captured for surveillance. No report has described an investigation of adiaspore formation progress in the lung. After establishing an experimental mouse model of intratracheal adiaspiromycosis infection with the causative agent Emmonsia crescens, we observed adiaspore development. The spores grew and reached a plateau of growth at 70 days post-infection. The median adiaspore diameter showed a plateau of around 40 μm. The characteristic three-layer cell-wall structure of adiaspores was observed in the lung at 70 days post-infection. We examined infection with a few spores, which revealed that adiaspores in the mouse lung progressed from intratracheal infection of at least 400 spores. Moreover, we developed adiaspores in vitro by culture in fetal bovine serum. Although most spores broke, some large spores were intact. They reached about 50 μm diameter. Thick cell walls and dense granules were found as common points between in vitro adiaspores and in vivo adiaspores. These models are expected to be useful for additional investigations of E. crescens adiaspores and adiaspiromycosis.

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“…Terrestrial rodents and burrowing animals are most commonly represented. Rare reports concern domestic or farm animals including two dogs (Al-Doory et al 1971;Koller et al 1976), a goat (Koller and Helfer 1978), a horse (Pusterla et al 2002) and a deer (Matsuda et al 2015), although no voucher material is available to confirm the diagnoses. Approximately 50 cases of human pulmonary adiaspiromycosis have been reported from the Americas, Europe, and North Africa (England and Hochholzer 1993;Sigler 1998;Anstead et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis

et al. 2018

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The family Ajellomycetaceae (Onygenales) includes mammal-associated pathogens within the genera Blastomyces, Emmonsia, Histoplasma and Paracoccidioides, as well as the recently described genera, Emergomyces that causes disease in immunocompromised hosts, and Emmonsiellopsis, known only from soil. To further assess the phylogenetic relationships among and between members of these genera and several previously undescribed species, we sequenced and analyzed the DNA-directed RNA polymerase II (rPB2), translation elongation factor 3-a (TEF3), b-tubulin (TUB2), 28S large subunit rDNA (LSU) and the internal transcribed spacer regions (ITS) in 68 strains, in addition to morphological and physiological investigations. To better understand the thermal dimorphism among these fungi, the dynamic process of transformation from mycelial to yeast-like or adiaspore-like forms was also assessed over a range of temperatures (6-42°C). Molecular data resolved the relationships and recognized five major well-supported lineages that correspond largely to the genus level. Emmonsia, typified by Emmonsia parva, is a synonym of Blastomyces that also accommodates Blastomyces helicus (formerly Emmonsia helica). Emmonsia crescens is phylogenetically distinct, and found closely related to a single strain from soil without known etiology. Blastomyces silverae, Emergomyces canadensis, Emergomyces europaeus and Emmonsia sola are newly described. Almost all of the taxa are associated with human and animal disease. Emmonsia crescens, B. dermatitidis and B. parvus are prevalently associated with pulmonary disease in humans or animals. Blastomyces helicus, B. percursus, Emergomyces africanus, Es. canadensis, Es. europaeus, Es. orientalis and Es. pasteurianus (formerly Emmonsia pasteuriana) are predominantly found in human hosts with immune disorders; no animal hosts are known for these species except B. helicus.

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First detection of adiaspiromycosis in the lungs of a deer

Cited by 8 publications

References 8 publications

Pulmonary adiaspiromycosis in the Eurasian beaver (Castor fiber) inhabiting Poland

Pulmonary adiaspiromycosis in the Eurasian beaver (Castor fiber) inhabiting Poland

Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model

Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis

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