First detection of Corynebacterium ulcerans producing a diphtheria-like toxin in a case of human with pulmonary infection in the Rio de Janeiro metropolitan area, Brazil

Mattos‐Guaraldi, Ana Luíza; Sampaio, Jorge Luiz Mello; Santos, Cíntia Silva; Pimenta, Fabricia Pires; Pereira, Geraldo; Pacheco, Luis Gustavo Carvalho; Miyoshi, Anderson; Azevedo, Vasco; Moreira, Lilian O.; Gutiérrez, Francisco; Costa, J. L. F.; Costa-Filho, Rubens; Damasco, Paulo Vieira; Camello, Thereza Cristina Ferreira; Hirata, Raphael

doi:10.1590/s0074-02762008000400014

Cited by 45 publications

(31 citation statements)

References 21 publications

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“…The virulence factor in diphtheria is an exotoxin that targets host protein synthesis (125). Another important Corynebacterium pathogen is C. ulcerans, which is increasingly acknowledged as an emerging pathogen in various countries; infections with this species can mimic diphtheria because it harbors lysogenic-␤-corynephages that carry the the diphtheria toxin (DT) gene, which is responsible for most of the systemic symptoms of diphtheria (126). C. ulcerans also induces clinical symptoms in the lower respiratory tract, including pneumonia (127) and pulmonary granulomatous nodules (128).…”

Section: Figmentioning

confidence: 99%

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka

Vatsa

Sanchez

et al. 2016

Microbiol Mol Biol Rev

1,592

1,048

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SUMMARYActinobacteriaare Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and terrestrial ecosystems. ManyActinobacteriahave a mycelial lifestyle and undergo complex morphological differentiation. They also have an extensive secondary metabolism and produce about two-thirds of all naturally derived antibiotics in current clinical use, as well as many anticancer, anthelmintic, and antifungal compounds. Consequently, these bacteria are of major importance for biotechnology, medicine, and agriculture.Actinobacteriaplay diverse roles in their associations with various higher organisms, since their members have adopted different lifestyles, and the phylum includes pathogens (notably, species ofCorynebacterium,Mycobacterium,Nocardia,Propionibacterium, andTropheryma), soil inhabitants (e.g.,MicromonosporaandStreptomycesspecies), plant commensals (e.g.,Frankiaspp.), and gastrointestinal commensals (Bifidobacteriumspp.).Actinobacteriaalso play an important role as symbionts and as pathogens in plant-associated microbial communities. This review presents an update on the biology of this important bacterial phylum.

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Section: Figmentioning

confidence: 99%

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka

Vatsa

Sanchez

et al. 2016

Microbiol Mol Biol Rev

1,592

1,048

View full text Add to dashboard Cite

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“…DNase-positive results were mainly observed for C. ulcerans but not Corynebacterium pseudotuberculosis strains (Mattos-Guaraldi et al 2008a, Pimenta et al 2008). …”

Section: Ulcerans Screening Testsmentioning

confidence: 94%

“…The suspect bacterial isolate was identified as C. ulcerans by conventional biochemical assays and the semiautomated APICoryne System (BioMérrieux, Lyon, France) (Efstratiou and George 1999, Funke and Bernard 2007, Mattos-Guaraldi et al 2008a). …”

Section: Ulcerans Phenotypic Characterizationmentioning

confidence: 99%

“…ulcerans can produce diphtheria (DT) and=or phospholipase D (Pld) toxins and may cause human infections mimicking cutaneous and classical respiratory DT with pseudomembranes (Wagner et al 2001, Dewinter et al 2005, Tiwari et al 2008. C. ulcerans is also able to induce clinical signs in the lower respiratory tract such as pneumonia (Hommez et al 1999, Hatanaka et al 2003, Mattos-Guaraldi et al 2008a) and granulomatous nodules in the lungs (Desseau et al 1995). Similar to nontoxinogenic Corynebacterium diphtheriae strains, the pathogenicity of some C. ulcerans strains may be independent of the DT production.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we described the first case of C. ulcerans human infection in Brazil, and the source of infection was undetermined (Mattos-Guaraldi et al 2008a). No reports of C. ulcerans infections in animals in the developing countries were found in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Corynebacterium ulceransIsolated from an Asymptomatic Dog Kept in an Animal Shelter in the Metropolitan Area of Rio de Janeiro, Brazil

Dias

Silva

Pereira

et al. 2010

Vector-Borne and Zoonotic Diseases

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Corynebacterium ulcerans was isolated from nares of one asymptomatic dog kept in an animal shelter in the metropolitan area of Rio de Janeiro, Brazil. The RNA polymerase beta subunit-encoding gene was sequenced to confirm the species identity. C. ulcerans strains producing phospholipase D, but not diphtheria toxin, are able to cause severe disease in humans, such as pneumonia and granulomatous nodules in pulmonary tissues. The infection rate varies really widely by region, probably because of the variations in the reported infection rates. Dogs with unapparent C. ulcerans infections may be considered as potentially capable of infecting other animals and humans, including pet owners. Medical and veterinary staff should be aware that asymptomatic animals can carry C. ulcerans and cooperate in eliminating infections and monitoring animals also in the developing countries.

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Coryneform Gram‐Positive Rods

Mattos‐Guaraldi,

Santos,

Vieira

2023

ClinMicroNow

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This chapter presents Coryneform bacteria comprising aerobically or facultatively anaerobically growing, asporogenous, non‐acid fast Gram‐positive rods with irregular morphology. Establishing the clinical significance of coryneform bacteria can be difficult for caregivers and microbiologists. Corynebacterium spp. form the predominant group and include diphtheria toxin (DT)‐producing Corynebacterium diphtheriae , the causative agent of classic diphtheria, which was once a major cause of illness and death among children. Laboratory procedures for identification of Corynebacterium spp. and other coryneform bacteria include collection and transport of clinical samples, isolation practices, culture conditions, phenotypic and molecular assays, as well as antimicrobial susceptibility testing. Molecular techniques have been increasingly used in microbiology laboratories for the identification of Corynebacterium species and other coryneform bacteria. Detection of antibodies directed against DT is the only established serologic test for coryneform bacteria.

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First detection of Corynebacterium ulcerans producing a diphtheria-like toxin in a case of human with pulmonary infection in the Rio de Janeiro metropolitan area, Brazil

Cited by 45 publications

References 21 publications

Taxonomy, Physiology, and Natural Products of Actinobacteria

Taxonomy, Physiology, and Natural Products of Actinobacteria

Corynebacterium ulceransIsolated from an Asymptomatic Dog Kept in an Animal Shelter in the Metropolitan Area of Rio de Janeiro, Brazil

Coryneform Gram‐Positive Rods

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