First detection of
            <i>Feline morbillivirus</i>
            infection in white‐eared opossums (
            <i>Didelphis albiventris</i>
            , Lund, 1840), a non‐feline host

Lavorente, Fernanda Louise Pereira; Matos, Andressa Maria Rorato Nascimento de; Lorenzetti, Elis; Oliveira, Marcos Vinicius; Ferreira, Fernanda Pinto; Michelazzo, Mariana de Mello Zanim; Viana, Nayara Emily; Lunardi, Michele; Headley, Selwyn Arlington; Alfieri, Amauri Alcindo; Alfieri, A.A.

doi:10.1111/tbed.14109

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…These wild cats have recently been shown to harbour FeMV; thus, they serve as new susceptible hosts for FeMV infection (Piewbang, Chaiyasak et al., 2020; Sieg et al., 2020). Recently, the FeMV was identified in the opossums, a non‐feline host (Lavorente et al., 2022), indicating extended information of the susceptible host of the FeMV. This information demonstrates the infectivity of FeMV in these wild species, and it also demonstrates that the virus can be circulated between domestic and wild felid animals in nature.…”

Section: Introductionmentioning

confidence: 99%

Feline morbillivirus‐1 in dogs with respiratory diseases

Piewbang

Wardhani

Dankaona

et al. 2021

Transbounding Emerging Dis

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Feline morbillivirus‐1 (FeMV‐1) is a viral pathogen associated with kidney disease in domestic cats and wild felids. We initially identified the FeMV‐1 from the lung of a necropsied dog with severe pulmonary disease by the reverse transcription polymerase chain reaction (RT‐PCR). Thereafter, we investigated FeMV‐1 in nasal and oral swab samples from 73 healthy and 113 dogs with respiratory illnesses. We found polymerase chain reaction (PCR)‐positive FeMV‐1 from only 14/113 (12.39%) dogs with respiratory disease (p = .001). Of these 14 dogs, six were co‐infected with other canine respiratory viruses (6/14; 42.86%). Two independent immunohistochemistry procedures, using antibodies against matrix and phosphoprotein of FeMV‐1, confirmed the presence of FeMV‐1 in lung tissues of two necropsied dogs (out of a total of 22 dogs, 9.09%) that died from respiratory disease. This finding corresponded to transmission electron microscopy findings that paramyxoviral particles exist in lung epithelia. FeMV‐1 antigen localization was also evident in the kidney, lymphoid and brain tissues of two deceased dogs. FeMV‐1 was successfully isolated from a necropsied dog and from two living dogs, all with respiratory illnesses, which supports FeMV infection in dogs. The detection of FeMV‐1 in dog tissues expands the known tropism of this virus to a non‐felid host. Our findings indicate that FeMV‐1, alone or in co‐infection with other viral pathogens, might contribute to respiratory illness and death in dogs.

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Section: Introductionmentioning

confidence: 99%

Feline morbillivirus‐1 in dogs with respiratory diseases

Piewbang

Wardhani

Dankaona

et al. 2021

Transbounding Emerging Dis

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“…The host spectrum of FeMV appears to also include noncarnivore species. Indeed, in Brazil, FeMV RNA was detected in a synanthropic marsupial, the white-eared opossum (Didelphis albiventris), and an FeMV strain from an opossum was isolated in Crandell Rees feline kidney lineage cells [39]. On phylogenetic analysis, the FeMV opossum strain clustered with FeMV-GT1 but formed a new branch [39].…”

Section: Virus Properties and Host Spectrummentioning

confidence: 99%

Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats

Pennisi,

Belák,

Tasker

et al. 2023

Viruses

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Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously.

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“…Surprisingly, it is also identified on other non-felidae species such as dog and opossum (Lavorente et al, 2021;Piewbang et al, 2021b). According to genomic characterization, FeMV forms two distinct genotypes.…”

Section: Feline Morbillivirus (Femv)mentioning

confidence: 99%

Associations of feline paramyxoviruses with pathological lesions in cat kidneys

Zahro

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Paramyxoviruses in cats composing of feline paramyxovirus (FPaV), feline morbillivirus genotype 1 (FeMV-1), and feline morbillivirus genotype 2 (FeMV-2). These viruses had been recently suggested to be associated with kidney disease in cats. However, pathological consequence of infection is remained restricted. This study aimed to investigate the association of paramyxovirus infection and pathological consequence in cats' kidney. Renal fresh tissues were collected from routine necropsy in Department of Pathology, Faculty of Veterinary Science, Then, tissues were histopathologically categorized into normal group and pathologic group. To screen paramyxovirus infection, reverse-transcription polymerase chain reaction (RT-PCR) assays using Res-Mor-Hen pan-primer set and specific primer set for each virus were carried out. Then, RT-PCR positive cases were employed for special staining determination using Periodic acid-Schiff (PAS) and Masson Trichrome (MT), followed by immunohistochemistry (IHC) and in situ hybridization (ISH). Furthermore, apoptotic activity assay was employed to detect the expression of cleaved caspase 3. Semiquantitative scorings were carried out for positive cases according to histopathological parameters such as degree of interstitial inflammation, tubular detachment, fibrosis, and apoptotic activity. The statistic data was evaluated using Spearman correlation coefficient with two-tailed test and p<0.05. The result of molecular detection revealed that nine samples were positive only for FeMV-1 infection. All FeMV-1 positive cases belonged to renal pathologic group. In each case, lymphoplasmacytic interstitial inflammation was observed. Immunostaining signal was observed on seven cases. However, ISH signal was exhibited by all cases. Interestingly, both IHC and ISH signals were expressed in both nucleus and cytoplasm of tubular epithelial cells. Association between FeMV-1 infection and histopathological parameters suggested that FeMV-1 infection would likely increase the apoptotic activity in infected kidneys. The presence of lymphoplasmacytic inflammation might be evidence that FeMV using signaling lymphocyte activation molecules (SLAM; CD150) that expressed on lymphoplasmacytic inflammatory cell as a viral receptor. Furthermore, viral localization would likely suggest that FeMV-1 did not only undergo replication and virion assembly in cytoplasm, but also in nucleus of tubular epithelial cells. Moreover, the apoptotic activity assay would likely to suggest that FeMV ruling caspase-dependent apoptotic activity.

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First detection of Feline morbillivirus infection in white‐eared opossums ( Didelphis albiventris , Lund, 1840), a non‐feline host

Cited by 7 publications

References 39 publications

Feline morbillivirus‐1 in dogs with respiratory diseases

Feline morbillivirus‐1 in dogs with respiratory diseases

Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats

Associations of feline paramyxoviruses with pathological lesions in cat kidneys

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