First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis

T helper (Th)2 cells have been proposed to play a neuroprotective role in multiple sclerosis (MS). This is mainly based on “loss-of-function” studies in an animal model for MS, experimental autoimmune encephalomyelitis (EAE), using blocking antibodies against Th2 related cytokines, and knockout mice lacking Th2-related molecules. We tested whether an increase of Th2 responses (“gain-of-function” approach) could alter EAE, the approach of novel GATA binding protein 3 (GATA3)-transgenic (tg) mice that overexpress GATA3, a transcription factor required for Th2 differentiation. In EAE induced with myelin oligodendrocyte glycoprotein (MOG)35–55 peptide, GATA3-tg mice had a significantly delayed onset of disease and a less severe maximum clinical score, compared with wild-type C57BL/6 mice. Histologically, GATA3-tg mice had decreased levels of meningitis and demyelination in the spinal cord, and anti-inflammatory cytokine profiles immunologically, however both groups developed similar levels of MOG-specific lymphoproliferative responses. During the early stage, we detected higher levels of interleukin (IL)-4 and IL-10, with MOG and mitogen stimulation of regional lymph node cells in GATA3-tg mice. During the late stage, only mitogen stimulation induced higher IL-4 and lower interferon-γ and IL-17 production in GATA3-tg mice. These results suggest that a preexisting bias toward a Th2 immune response may reduce the severity of inflammatory demyelinating diseases, including MS.

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“…Eosinophilic infiltration, has been reported in the CNS in human MS-like disease, atopic myelitis [58]. In asthma, Nakamura et al .…”

Section: Resultsmentioning

confidence: 99%

Regulation of an Autoimmune Model for Multiple Sclerosis in Th2-Biased GATA3 Transgenic Mice

Fernando

Omura

Sato

et al. 2014

IJMS

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“…The first diagnostic criteria for AM with special reference to discrimination from myelitis-onset multiple sclerosis have been proposed by Isobe et al which demonstrated 93.3% sensitivity and 93.3% specificity for AM against myelitis-onset MS, with 82.4% positive predictive value and 97.7% negative predictive value [5]. According to this criterion our patient is a definite case of AM.…”

Section: Discussionmentioning

confidence: 75%

“…These features were similar to those reported in 14 AM patients from Korea, although a few differences were noted, such as lower prevalence of a history of atopic diseases, thoracic cord preference, and higher frequencies of gadolinium-enhanced lesions compared with nationwide surveys in Japan [4]. The first diagnostic criteria for AM with special reference to discrimination from myelitis-onset multiple sclerosis (MS) have been proposed by Isobe et al which demonstrated 93.3% sensitivity and 93.3% specificity for AM against myelitis-onset MS, with 82.4% positive predictive value and 97.7% negative predictive value [5].…”

Section: Introductionmentioning

confidence: 99%

Atopic myelitis: A case report from India

Praveen-kumar

Kumar

Agadi

2014

Clinical Neurology and Neurosurgery

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“…As a reason for multifocal hyperintense spinal cord signal, we considered the possibility of neuroinflammatory disorders, such as multiple sclerosis, neuromyelitis optica, or connective tissue disease, sarcoidosis, Behcet's disease, and so on [3–6], other than atopic myelitis, but we were skeptical about these possibilities according to the results of blood biochemical study. The diagnosis of atopic myelitis was made based on the blood biochemical findings, and steroid pulse therapy was performed using methylprednisolone (1000 mg/day, for 3 days).…”

Section: Medical Therapy and Posttherapy Coursementioning

confidence: 99%

A Case of Atopic Myelitis with Cervical Cavernous Angioma

Fukuda¹,

Manabe²,

Sasaki³

et al. 2017

Case Reports in Medicine

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Atopic myelitis, a type of myelitis which appears in patients with elevated serum levels of immunoglobulin E (IgE), occurs more commonly in the cervical spinal cord, but this mechanism has not yet been elucidated. Herein, we experienced a case of atopic myelitis developed during the growth of cervical cavernous angioma caused by bleeding. A 37-year-old woman suffered from hand swelling caused by a house cat licking. At the same time when cavernous angioma had grown, she experienced a numbness in her four extremities, and multifocal peritumoral hyperintense spinal cord signals were seen. The diagnosis of atopic myelitis was made because we observed significantly elevated levels of specific IgE antibody to cat dander. Symptoms disappeared immediately after steroid pulse therapy. We subsequently resected a cavernous angioma, and eosinophil invasion was found inside it. This is the first case report of atopic myelitis which developed in association with spinal cord vascular lesions. A local blood-brain barrier breakdown due to hemorrhagic lesions of the spinal cord may have contributed to the onset of atopic myelitis.

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First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis

Cited by 29 publications

References 24 publications

Regulation of an Autoimmune Model for Multiple Sclerosis in Th2-Biased GATA3 Transgenic Mice

Regulation of an Autoimmune Model for Multiple Sclerosis in Th2-Biased GATA3 Transgenic Mice

Atopic myelitis: A case report from India

A Case of Atopic Myelitis with Cervical Cavernous Angioma

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