First Draft Genome Sequence of a Clinical Strain of Nocardia cerradoensis

Carrasco, Gema; Monzón, Sara; Jiménez, Pilar; Cuesta, Isabel; Bartolomé-Álvarez, Joaquín; Valdezate, Sylvia

doi:10.1128/genomea.00551-17

Cited by 2 publications

(1 citation statement)

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“…Reports involving studies on the whole genome sequence (WGS) also provided insights into the molecular basis of resistance towards different antibiotics exhibited by different species of Nocardia [22][23][24][25]. Studies on the WGSs of N. cyriacigeorgica strains helped in understanding the physiology, evolution and adaptation of the environmental bacteria for being converted into a pathogenic one [26,27].Genome based analysis of different species of Nocardia revealed some of them to harbour genes responsible for the production of important secondary metabolites like polyketide synthase (PKS-I) and non-ribosomal peptide synthetases (NRPS) [28,29]. Species belonging to the genus Nocardia were also reported to produce valuable metabolites like antibacterial compounds, UVprotectant molecules, immune suppressant, nocavionin and nocobactin derivatives with anti muscarinic activities [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Insights from the comparative genome analysis of natural rubber degrading Nocardia species

Sarkar¹

2021

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Nocardia are known to be a facultative human pathogen and can cause infection in immune compromised patients. Though the details research on the virulence factors of Nocardia are scanty but numerous genes that code such factors were reported from different species of Nocardia. Despite of the presence of several virulence factors, species of this genus have been shown to have role in remediation of many toxic and hazardous materials from the environment. In this study, genome sequences of rubber degrading Nocardia sp. BSTN01 and N. nova SH22a have been analyzed to locate the potential virulence genes. Also, the genomes of facultative pathogenic Nocardia like, N. africana, N. brasiliensis, N. kruczakiae, N. transvalensis and N. veterana have been analyzed to find the gene encoding latex clearing protein (Lcp), a rubber oxygenase enzyme of Gram-positive action bacteria. The study provides an insight about the potentiality of rubber-degrading Nocardia species to emerge as future human pathogens and also the probability of a serious concern if the studied facultative pathogens of Nocardia like N. africana, N. brasiliensis, N. kruczakiae, N. transvalensis and N. veteranaare capable of degrading rubber, a regularly used material in clinics. Moreover, use of such possible pathogenic strains for their known role in bioremediation of rubber waste from the environment might be deleterious.

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Section: Introductionmentioning

confidence: 99%