Women with subfertility or recurrent miscarriage were recruited to a two-centre RCT where they were randomised to either the online lifestyle coaching platform 'Smarter Pregnancy' (intervention) or periconceptional advice provided by NHS websites (control). Participants completed a lifestyle questionnaire at baseline, 6, 12, 18 and 24 weeks; the results were used to tailor lifestyle coaching in the intervention group. At baseline, 12 and 24 weeks, composite risk scores (CRS) were calculated. A lower CRS corresponds with a healthier lifestyle.
ResultsOf the 400 women recruited, 262 women were randomised (131 in each arm). At 12 weeks, there was a reduction in CRS (includes risk score for intake of folic acid, vegetables and fruits, smoking and alcohol) in the intervention vs control arms. After correcting for baseline, the difference in the CRS between intervention and control were -0.47 (95% CI -0.97, 0.02) at 12 weeks and -0.32 (95% CI -0.82, 0.15) at 24 weeks. There was a statistically significant reduction in lifestyle risk scores in women with a BMI ≥25kg/m 2 compared to those with a BMI <25kg/m 2 . The odds of being pregnant at 24 weeks was increased in the intervention vs control (OR 2.83, 95% CI 0.35, 57.76).
ConclusionsThe 'Smarter Pregnancy' coaching platform is more effective in delivering lifestyle advice and modulating behaviours to support women with a history of subfertility or recurrent miscarriage than standard online NHS advice.