First Episode of Psychosis Following the Covid-19 Vaccination - A Case Series

Borovina, Tonka; Popović, Jelena; Mastelić, Tonći; Ercegovac, Mirjana Sucevic; Kustura, Lea; Uglešić, Boran; Glavina, Trpimir

doi:10.24869/psyd.2022.377

Cited by 6 publications

(5 citation statements)

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“…As well as, we can preclude that had been only a coincidence between vaccination and onset of psychosis. Nonetheless, our report is similar to others described [9,11,13,14] in the sense of there were no past or family history of mental disorders and there were a close temporal relationship between onset of symptoms with vaccination. Reinforcing the hypothesis of the COVID-19 vaccine can cause extremely immune response predisposing to a psychotic condition in very small number of people.…”

Section: Discussionsupporting

confidence: 91%

Refractoy psychosis after mRNA COVID-19 vaccine

Neves¹,

Simon²,

Neto³

et al. 2023

Debates em Psiquiatria

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Introduction: The vaccination against SARS-CoV-2 has shown efficacy in decreasing morbidity and mortality. There are several systemic side effects and some neuropsychiatric manifestations described. Case report: A 38-year-old woman was admitted to the Psychiatry of the Conjunto Hospitalar de Sorocaba presenting disorganized behavior and aggressiveness. Six months ago, she received the first dose of the mRNA vaccine for COVID-19 and, around 24 hours later, had systemic adverse effects followed by aggressiveness and delusional thinking of persecutory nature. She had no past clinical or psychiatric reports. Previously, she was perfectly functional. We performed an extensive clinical-laboratorial investigation, and all tests were negatives. Several pharmacological therapies with antipsychotics and mood stabilizers were used, but after more than four months of hospitalization, the improvements observed were just in orientation and behavior, remaining with symptoms of psychosis. Discussion: This is the first report of refractory psychosis after COVID-19 immunization with no improvement of symptoms; there have been related psychoses after COVID-19 immunization. It is suggested that the psychosis occurs by the intense cytokine storm, leading to a high pro-inflammatory status. It is hypothesized that vaccination causes a strong immune response against the SARS-CoV-19; therefore, similarly mechanisms could underlie the psychosis after COVID-19 immunization.

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Section: Discussionsupporting

confidence: 91%

Refractoy psychosis after mRNA COVID-19 vaccine

Neves¹,

Simon²,

Neto³

et al. 2023

Debates em Psiquiatria

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“…There is evidence that FEP patients may benefit the most from the prescription of LAIs, since there is a high response rate to initial antipsychotic treatment in FEP (Agid et al, 2011) and LAIs in various studies proved to be more effective than oral medications in preventing hospitalizations and relapses (Ceraso et al, 2020;Kishimoto et al, 2021;Tiihonen et al, 2011). LAIs should be considered as a valid and effective alternative to oral medications in FEP patients (Cervone et al, 2015;Kane et al, 2020;Stahl, 2014).…”

Section: Discussionmentioning

confidence: 99%

Dimensions and predictors of clinical and personal recovery in first‐episode psychoses: Results from a cross‐sectional study

Ferrara,

Zaffarami,

Simonelli

et al. 2024

Early Intervention Psych

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IntroductionFirst episode psychosis (FEP) services ensure higher recovery rates compared to usual care. The aim of this study was to investigate the different dimensions of recovery and its predictors.MethodsThis cross‐sectional study recruited within those admitted to the Ferrara FEP service since 2012 that at the time of analysis were still receiving psychiatric care. At admission, demographic, social and clinical information were collected. In September 2022, patients were assessed with the Health of the Nation Outcome Scale to evaluate clinical/functional recovery, the Recovery Assessment Scale to evaluate personal recovery, and the G12 item of the Positive and Negative Syndrome Scale to evaluate insight. Patients in recovery were compared to those not in recovery by bivariate analyses. Adjusted logistic regressions were performed to investigate predictors of recovery.ResultsWithin 141 admitted, and 105 still receiving care, 54 patients completed the assessment. Most (51.9%) were in clinical/functional, 61.1% in personal recovery, and 38.8% both. Psychiatric hospitalization positively predicted clinical/functional recovery, whereas being prescribed oral antipsychotics was a negative predictor. Personal recovery was predicted by male sex and showed a negative association with overall severity of symptomatology. Those in personal recovery were more likely to have been prescribed long‐acting antipsychotics, but this was not significant in the multivariable analysis. Poor insight negatively predicted clinical/functional recovery but had no impact on personal recovery.ConclusionOur findings confirm that clinical/functional and personal recovery are semi‐independent dimensions and not always overlap. Further research is needed to promote interventions targeted at all recovery dimensions.

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“…A similar case study published in 2022 explored the possibility of cognitive deficits post covid 19 vaccines, and it concluded that the onset of acute cognitive deficits and memory impairments (psychosis) can be a complication after the vaccine and it requires further study by neurologists and physicians. [17]. A study has reported that the most common neurological symptoms post covid vaccines include dizziness, headache, pain, muscle spasms, myalgia, and paresthesia [18].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive survey on the beliefs, perceptions, and clinical manifestations of pre and post Covid-19 vaccinations among physiotherapy students in the United Arab Emirates

Almheiri

Hazari

Kumar

et al. 2023

Preprint

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Background: The World Health Organization has defined Coronavirus Disease (COVID-19) as an infectious pandemic, caused by a newly discovered SARS-CoV-2 virus. Students relied heavily on the internet, social media, parents, and friends, in addition to medical advice for information on its presentation, complications, prevention, and management. It is evident from the literature that healthcare professionals including students who play an important role in the healthcare system may be lacking important information on COVID-19 vaccinations. Thus, the study aims to identify and compare the pre-post covid-19 vaccination-related essential information among Physical Therapy university students.Methods: A cross-sectional survey was conducted among physiotherapy university students in the United Arab Emirates using a self-administrated structured questionnaire. The questionnaire comprised three sections covering beliefs, perceptions, and clinical manifestations of the pre and post-COVID- 19 vaccination. The survey was shared with more than 300 students through email and social platforms during the time between January 2022 till December 2022.Results: The majority of the physiotherapy students believed the vaccines to be safe (71.3%) due to multiple reasons while others did not believe in the effectiveness of the vaccine (28.7%). Some students did report unusual symptoms (painful periods, hair loss, forgetfulness) after the vaccine (10%). Similar findings were reported for family members as well (14%). Students had a positive perception of the vaccine and reported willingness to take it even if not mandatory (68%).Conclusion: Some students did believe in the safety of the vaccine due to multiple reasons while some did not due to fear of long-term side effects and personal choices. The finding of the study could be useful to create confidence as well as awareness among physiotherapy students as they are often invited to aid during medical pandemics such as Covid 19. Also, higher rates of vaccination among healthcare professionals will impart higher acceptance in the medical organization due to safety guidelines. This could also help to counsel other students against fear and apprehension towards the vaccination of such kind in the future.

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First Episode of Psychosis Following the Covid-19 Vaccination - A Case Series

Cited by 6 publications

References 0 publications

Refractoy psychosis after mRNA COVID-19 vaccine

Refractoy psychosis after mRNA COVID-19 vaccine

Dimensions and predictors of clinical and personal recovery in first‐episode psychoses: Results from a cross‐sectional study

A comprehensive survey on the beliefs, perceptions, and clinical manifestations of pre and post Covid-19 vaccinations among physiotherapy students in the United Arab Emirates

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